Atlas of Genetics and Cytogenetics in Oncology and Haematology

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t(6;17)(p21;p13) RUNX2/USP6

Written08-2018Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)


Atlas_Id 106950
Phylum Bones: Bones::
WHO/OMS Classification Bones
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Bones: Aneurysmal bone cyst

Genes involved and Proteins

Gene NameRUNX2
Location 6p21.1

Gene NameUSP6
Location 17p13.2


Anchored multiplex PCR for targeted next-generation sequencing reveals recurrent and novel USP6 fusions and upregulation of USP6 expression in aneurysmal bone cyst
Guseva NV, Jaber O, Tanas MR, Stence AA, Sompallae R, Schade J, Fillman AN, Miller BJ, Bossler AD, Ma D
Genes Chromosomes Cancer 2017 Apr;56(4):266-277
PMID 27910166
Gene fusions PAFAH1B1-USP6 and RUNX2-USP6 in aneurysmal bone cysts identified by next generation sequencing
Warren M, Xu D, Li X
Cancer Genet 2017 Apr;212-213:13-18
PMID 28449806

Translocations implicated (Data extracted from papers in the Atlas)

 t(6;17)(p21;p13) RUNX2/USP6

External links

Mitelman database t(6;17)(p21;p13) [CaseList]     t(6;17)(p21;p13) [Transloc - MCList]   RUNX2/USP6 Fusion - MCList]
COSMIC[ RUNX2 ]   [ USP6 ]
arrayMap arrayMap ((UZH-SIB Zurich)   [auto + random 100 samples .. if exist ]   [tabulated segments]
Disease databaset(6;17)(p21;p13) RUNX2/USP6
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 28 16:43:36 CET 2018

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