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FGFR1/TACC1 (8p11)

Written08-2018Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

Atlas_Id 107999
Phylum Nervous system: Central Nervous system::
WHO/OMS Classification Nervous system
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Central Nervous system: Astrocytoma, grade III-IV/Glioblastoma

Disease Central Nervous system: Astrocytoma, pilocytic/juvenile

Genes involved and Proteins

Gene NameFGFR1
Location 8p11.23

Gene NameTACC1
Location 8p11.22

Bibliography

Transforming fusions of FGFR and TACC genes in human glioblastoma
Singh D, Chan JM, Zoppoli P, Niola F, Sullivan R, Castano A, Liu EM, Reichel J, Porrati P, Pellegatta S, Qiu K, Gao Z, Ceccarelli M, Riccardi R, Brat DJ, Guha A, Aldape K, Golfinos JG, Zagzag D, Mikkelsen T, Finocchiaro G, Lasorella A, Rabadan R, Iavarone A
Science 2012 Sep 7;337(6099):1231-5
PMID 22837387
 
Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma
Fontebasso AM, Papillon-Cavanagh S, Schwartzentruber J, Nikbakht H, Gerges N, Fiset PO, Bechet D, Faury D, De Jay N, Ramkissoon LA, Corcoran A, Jones DT, Sturm D, Johann P, Tomita T, Goldman S, Nagib M, Bendel A, Goumnerova L, Bowers DC, Leonard JR, Rubin JB, Alden T, Browd S, Geyer JR, Leary S, Jallo G, Cohen K, Gupta N, Prados MD, Carret AS, Ellezam B, Crevier L, Klekner A, Bognar L, Hauser P, Garami M, Myseros J, Dong Z, Siegel PM, Malkin H, Ligon AH, Albrecht S, Pfister SM, Ligon KL, Majewski J, Jabado N, Kieran MW
Nat Genet 2014 May;46(5):462-6
PMID 24705250
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(8;8)(p11;p11) FGFR1/TACC1

External links

Mitelman database t(8;8)(p11;p11) [CaseList]     t(8;8)(p11;p11) [Transloc - MCList]   FGFR1/TACC1 Fusion - MCList]
COSMIC[ FGFR1 ]   [ TACC1 ]
arrayMap arrayMap ((UZH-SIB Zurich)   [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease databaseFGFR1/TACC1 (8p11)
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed


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indexed on : Wed Nov 28 16:46:04 CET 2018


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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.