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t(8;8)(q12;q24) PVT1/CHD7

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)


Atlas_Id 6703
Phylum Lung::
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

Clinics and Pathology

Disease Lung:Lung, Heart, Skin, Other: Lung: Small cell carcinoma: t(8;8)(q12;q24) PVT1/CHD7

Genes involved and Proteins

Gene NamePVT1
Location 8q24.21

Gene NameCHD7
Location 8q12.2


Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing
Campbell PJ, Stephens PJ, Pleasance ED, O'Meara S, Li H, Santarius T, Stebbings LA, Leroy C, Edkins S, Hardy C, Teague JW, Menzies A, Goodhead I, Turner DJ, Clee CM, Quail MA, Cox A, Brown C, Durbin R, Hurles ME, Edwards PA, Bignell GR, Stratton MR, Futreal PA
Nat Genet 2008 Jun;40(6):722-9
PMID 18438408
A small-cell lung cancer genome with complex signatures of tobacco exposure
Pleasance ED, Stephens PJ, O'Meara S, McBride DJ, Meynert A, Jones D, Lin ML, Beare D, Lau KW, Greenman C, Varela I, Nik-Zainal S, Davies HR, Ordoñez GR, Mudie LJ, Latimer C, Edkins S, Stebbings L, Chen L, Jia M, Leroy C, Marshall J, Menzies A, Butler A, Teague JW, Mangion J, Sun YA, McLaughlin SF, Peckham HE, Tsung EF, Costa GL, Lee CC, Minna JD, Gazdar A, Birney E, Rhodes MD, McKernan KJ, Stratton MR, Futreal PA, Campbell PJ
Nature 2010 Jan 14;463(7278):184-90
PMID 20016488

Translocations implicated (Data extracted from papers in the Atlas)

 t(8;8)(q12;q24) PVT1/CHD7

External links

Mitelman database t(8;8)(q12;q24) [CaseList]    t(8;8)(q12;q24) [Transloc - MCList] PVT1/CHD7 [Fusion - MCList]
COSMIC[ PVT1 ]   [ CHD7 ]
arrayMap arrayMap ((UZH-SIB Zurich)   [auto + random 100 samples .. if exist ]   [tabulated segments]
Disease databaset(8;8)(q12;q24) PVT1/CHD7
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed

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indexed on : Fri Mar 9 18:01:35 CET 2018

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