Atlas of Genetics and Cytogenetics in Oncology and Haematology

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t(8;11)(p12;q14) TENM4::NRG1

(Note : for Links provided by Atlas : click)


Atlas_Id 107817
Phylum Female organs: Breast::
WHO/OMS Classification Female organs
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Breast: Adenocarcinoma

Genes involved and Proteins

Gene NameTENM4
Location 11q14.1

Gene NameNRG1
Location 8p12


gamma-heregulin is the product of a chromosomal translocation fusing the DOC4 and HGL/NRG1 genes in the MDA-MB-175 breast cancer cell line
Wang XZ, Jolicoeur EM, Conte N, Chaffanet M, Zhang Y, Mozziconacci MJ, Feiner H, Birnbaum D, Pébusque MJ, Ron D
Oncogene 1999 Oct 7;18(41):5718-21
PMID 10523851
Gamma-heregulin: a fusion gene of DOC-4 and neuregulin-1 derived from a chromosome translocation
Liu X, Baker E, Eyre HJ, Sutherland GR, Zhou M
Oncogene 1999 Nov 25;18(50):7110-4
PMID 10597312
A novel bioinformatics pipeline for identification and characterization of fusion transcripts in breast cancer and normal cell lines
Asmann YW, Hossain A, Necela BM, Middha S, Kalari KR, Sun Z, Chai HS, Williamson DW, Radisky D, Schroth GP, Kocher JP, Perez EA, Thompson EA
Nucleic Acids Res 2011 Aug;39(15):e100
PMID 21622959

Translocations implicated (Data extracted from papers in the Atlas)

 t(8;11)(p12;q14) TENM4/NRG1

External links

Mitelman database t(8;11)(p12;q14) [CaseList]     t(8;11)(p12;q14) [Transloc - MCList]   TENM4/NRG1 Fusion - MCList]
COSMIC[ TENM4 ]   [ NRG1 ]
arrayMap arrayMap ((UZH-SIB Zurich)   [auto + random 100 samples .. if exist ]   [tabulated segments]
Disease databaset(8;11)(p12;q14) TENM4::NRG1
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed

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indexed on : Tue Oct 12 14:55:37 CEST 2021

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