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t(8;15)(q24;q21) HMGN2P46/MYC

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

Atlas_Id 107664
Phylum Male organs: Prostate::
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Male organs: Prostate:Adenocarcinoma

Genes involved and Proteins

Gene NameHMGN2P46
Location 15q21.1

Gene NameMYC
Location 14q23.3

Bibliography

Integrated genome and transcriptome sequencing identifies a novel form of hybrid and aggressive prostate cancer
Wu C, Wyatt AW, Lapuk AV, McPherson A, McConeghy BJ, Bell RH, Anderson S, Haegert A, Brahmbhatt S, Shukin R, Mo F, Li E, Fazli L, Hurtado-Coll A, Jones EC, Butterfield YS, Hach F, Hormozdiari F, Hajirasouliha I, Boutros PC, Bristow RG, Jones SJ, Hirst M, Marra MA, Maher CA, Chinnaiyan AM, Sahinalp SC, Gleave ME, Volik SV, Collins CC
J Pathol 2012 May;227(1):53-61
PMID 22294438
 
From sequence to molecular pathology, and a mechanism driving the neuroendocrine phenotype in prostate cancer
Lapuk AV, Wu C, Wyatt AW, McPherson A, McConeghy BJ, Brahmbhatt S, Mo F, Zoubeidi A, Anderson S, Bell RH, Haegert A, Shukin R, Wang Y, Fazli L, Hurtado-Coll A, Jones EC, Hach F, Hormozdiari F, Hajirasouliha I, Boutros PC, Bristow RG, Zhao Y, Marra MA, Fanjul A, Maher CA, Chinnaiyan AM, Rubin MA, Beltran H, Sahinalp SC, Gleave ME, Volik SV, Collins CC
J Pathol 2012 Jul;227(3):286-97
PMID 22553170
 
nFuse: discovery of complex genomic rearrangements in cancer using high-throughput sequencing
McPherson A, Wu C, Wyatt AW, Shah S, Collins C, Sahinalp SC
Genome Res 2012 Nov;22(11):2250-61
PMID 22745232
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(8;15)(q24;q21) HMGN2P46/MYC

External links

Mitelman database t(8;15)(q24;q21) [CaseList]     t(8;15)(q24;q21) [Transloc - MCList]   HMGN2P46/MYC Fusion - MCList]
COSMIC[ HMGN2P46 ]   [ MYC ]
arrayMap arrayMap ((UZH-SIB Zurich)   [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease databaset(8;15)(q24;q21) HMGN2P46/MYC
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed


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indexed on : Fri Jun 22 18:04:12 CEST 2018


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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.