Atlas of Genetics and Cytogenetics in Oncology and Haematology

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t(8;22)(p21;q12) PPP2R2A/CHEK2

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Atlas_Id 107983
Phylum Lung, Heart, Skin, Other: Mediastinum::
WHO/OMS Classification Lung, Heart, Skin, Other
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Mediastinum: Teratoma (mature and immature)

Genes involved and Proteins

Gene NamePPP2R2A
Location 8p21.2

Gene NameCHEK2
Location 22q12.1


Fusion of the tumor-suppressor gene CHEK2 and the gene for the regulatory subunit B of protein phosphatase 2 PPP2R2A in childhood teratoma
Jin Y, Mertens F, Kullendorff CM, Panagopoulos I
Neoplasia 2006 May;8(5):413-8
PMID 16790090

Translocations implicated (Data extracted from papers in the Atlas)

 t(8;22)(p21;q12) PPP2R2A/CHEK2

External links

Mitelman database t(8;22)(p21;q12) [CaseList]     t(8;22)(p21;q12) [Transloc - MCList]   PPP2R2A/CHEK2 Fusion - MCList]
arrayMap arrayMap ((UZH-SIB Zurich)   [auto + random 100 samples .. if exist ]   [tabulated segments]
Disease databaset(8;22)(p21;q12) PPP2R2A/CHEK2
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed

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indexed on : Mon Sep 21 11:37:59 CEST 2020

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