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t(10;10)(q21;q26) FGFR2/BICC1

Written08-2018Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

Atlas_Id 100197
Phylum Digestive organs: Gallbladder::
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Gallbladder: Adenocarcinoma

Genes involved and Proteins

Gene NameFGFR2
Location 10q26.13

Gene NameBICC1
Location 10q21.1

Bibliography

Identification of targetable FGFR gene fusions in diverse cancers
Wu YM, Su F, Kalyana-Sundaram S, Khazanov N, Ateeq B, Cao X, Lonigro RJ, Vats P, Wang R, Lin SF, Cheng AJ, Kunju LP, Siddiqui J, Tomlins SA, Wyngaard P, Sadis S, Roychowdhury S, Hussain MH, Feng FY, Zalupski MM, Talpaz M, Pienta KJ, Rhodes DR, Robinson DR, Chinnaiyan AM
Cancer Discov 2013 Jun;3(6):636-47
PMID 23558953
 
Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma
Arai Y, Totoki Y, Hosoda F, Shirota T, Hama N, Nakamura H, Ojima H, Furuta K, Shimada K, Okusaka T, Kosuge T, Shibata T
Hepatology 2014 Apr;59(4):1427-34
PMID 24122810
 
Integrated genomic characterization reveals novel, therapeutically relevant drug targets in FGFR and EGFR pathways in sporadic intrahepatic cholangiocarcinoma
Borad MJ, Champion MD, Egan JB, Liang WS, Fonseca R, Bryce AH, McCullough AE, Barrett MT, Hunt K, Patel MD, Young SW, Collins JM, Silva AC, Condjella RM, Block M, McWilliams RR, Lazaridis KN, Klee EW, Bible KC, Harris P, Oliver GR, Bhavsar JD, Nair AA, Middha S, Asmann Y, Kocher JP, Schahl K, Kipp BR, Barr Fritcher EG, Baker A, Aldrich J, Kurdoglu A, Izatt T, Christoforides A, Cherni I, Nasser S, Reiman R, Phillips L, McDonald J, Adkins J, Mastrian SD, Placek P, Watanabe AT, Lobello J, Han H, Von Hoff D, Craig DW, Stewart AK, Carpten JD
PLoS Genet 2014 Feb 13;10(2):e1004135
PMID 24550739
 
New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing
Ross JS, Wang K, Gay L, Al-Rohil R, Rand JV, Jones DM, Lee HJ, Sheehan CE, Otto GA, Palmer G, Yelensky R, Lipson D, Morosini D, Hawryluk M, Catenacci DV, Miller VA, Churi C, Ali S, Stephens PJ
Oncologist 2014 Mar;19(3):235-42
PMID 24563076
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(10;10)(q21;q26) FGFR2/BICC1

External links

Mitelman database t(10;10)(q21;q26) [CaseList]     t(10;10)(q21;q26) [Transloc - MCList]   FGFR2/BICC1 Fusion - MCList]
COSMIC[ FGFR2 ]   [ BICC1 ]
arrayMap arrayMap ((UZH-SIB Zurich)   [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease databaset(10;10)(q21;q26) FGFR2/BICC1
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed


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indexed on : Fri Oct 5 17:31:13 CEST 2018


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jlhuret@AtlasGeneticsOncology.org.