Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

t(11;18)(q22;q21) BIRC3/MALT1

Written08-2018Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)


Atlas_Id 101025
Phylum Digestive organs: Stomach::
WHO/OMS Classification Digestive organs
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Stomach: Extranodal marginal zone B-cell lymphoma

Genes involved and Proteins

Gene NameBIRC3
Location 11q22.2

Gene NameMALT1
Location 18q21.32


The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas
Dierlamm J, Baens M, Wlodarska I, Stefanova-Ouzounova M, Hernandez JM, Hossfeld DK, De Wolf-Peeters C, Hagemeijer A, Van den Berghe H, Marynen P
Blood 1999 Jun 1;93(11):3601-9
PMID 10339464
API2-MALT1 chimeric transcripts involved in mucosa-associated lymphoid tissue type lymphoma predict heterogeneous products
Motegi M, Yonezumi M, Suzuki H, Suzuki R, Hosokawa Y, Hosaka S, Kodera Y, Morishima Y, Nakamura S, Seto M
Am J Pathol 2000 Mar;156(3):807-12
PMID 10702396
Incidence and subtype specificity of API2-MALT1 fusion translocations in extranodal, nodal, and splenic marginal zone lymphomas
Remstein ED, James CD, Kurtin PJ
Am J Pathol 2000 Apr;156(4):1183-8
PMID 10751343
The product of the t(11;18), an API2-MLT fusion, is an almost exclusive finding in marginal zone cell lymphoma of extranodal MALT-type
Maes B, Baens M, Marynen P, De Wolf-Peeters C
Ann Oncol 2000 May;11(5):521-6
PMID 10907943
Detection of t(11;18)(q21;q21) by interphase fluorescence in situ hybridization using API2 and MLT specific probes
Dierlamm J, Baens M, Stefanova-Ouzounova M, Hinz K, Wlodarska I, Maes B, Steyls A, Driessen A, Verhoef G, Gaulard P, Hagemeijer A, Hossfeld DK, De Wolf-Peeters C, Marynen P
Blood 2000 Sep 15;96(6):2215-8
PMID 10979968
Structure of the MLT gene and molecular characterization of the genomic breakpoint junctions in the t(11;18)(q21;q21) of marginal zone B-cell lymphomas of MALT type
Baens M, Steyls A, Dierlamm J, De Wolf-Peeters C, Marynen P
Genes Chromosomes Cancer 2000 Dec;29(4):281-91
PMID 11066071
Heterogeneity of the API2-MALT1 gene rearrangement in MALT-type lymphoma
Kalla J, Stilgenbauer S, Schaffner C, Wolf S, Ott G, Greiner A, Rosenwald A, Döhner H, Müller-Hermelink HK, Lichter P
Leukemia 2000 Nov;14(11):1967-74
PMID 11069033
The t(11; 18)(q21; q21) translocation in H
Nakamura T, Nakamura S, Yonezumi M, Seto M, Yokoi T
pylori-negative low-grade gastric MALT lymphoma Am J Gastroenterol
PMID 11095369
T(11;18)(q21;q21) is associated with advanced mucosa-associated lymphoid tissue lymphoma that expresses nuclear BCL10
Liu H, Ye H, Dogan A, Ranaldi R, Hamoudi RA, Bearzi I, Isaacson PG, Du MQ
Blood 2001 Aug 15;98(4):1182-7
PMID 11493468
T(11;18) is a marker for all stage gastric MALT lymphomas that will not respond to H
Liu H, Ye H, Ruskone-Fourmestraux A, De Jong D, Pileri S, Thiede C, Lavergne A, Boot H, Caletti G, Wündisch T, Molina T, Taal BG, Elena S, Thomas T, Zinzani PL, Neubauer A, Stolte M, Hamoudi RA, Dogan A, Isaacson PG, Du MQ
pylori eradication Gastroenterology
PMID 11984515
Clinicopathologic comparison between the API2-MALT1 chimeric transcript-positive and -negative gastric low-grade B-cell lymphoma of mucosa-associated lymphoid tissue type
Nakamura T, Nakamura S, Yokoi T, Suzuki H, Ohashi K, Seto M
Jpn J Cancer Res 2002 Jun;93(6):677-84
PMID 12079516
High frequency of t(11;18) in gastric mucosa-associated lymphoid tissue lymphomas in Taiwan, including one patient with high-grade transformation
Chuang SS, Lee C, Hamoudi RA, Liu H, Lee PS, Ye H, Diss TC, Dogan A, Isaacson PG, Du MQ
Br J Haematol 2003 Jan;120(1):97-100
PMID 12492583
Chromosomal translocation t(11;18)(q21;q21) in gastrointestinal mucosa associated lymphoid tissue lymphoma
Nakamura S, Matsumoto T, Nakamura S, Jo Y, Fujisawa K, Suekane H, Yao T, Tsuneyoshi M, Iida M
J Clin Pathol 2003 Jan;56(1):36-42
PMID 12499431
Mutual exclusion of t(11;18)(q21;q21) and numerical chromosomal aberrations in the development of different types of primary gastric lymphomas
Schreuder MI, Hoeve MA, Hebeda KM, Verdijk MA, Ligtenberg MJ, Bot FJ, Chott A, van Krieken JH
Br J Haematol 2003 Nov;123(4):590-9
PMID 14616961
Prognostic value of translocation t(11;18) in tumoral response of low-grade gastric lymphoma of mucosa-associated lymphoid tissue type to oral chemotherapy
Lévy M, Copie-Bergman C, Gameiro C, Chaumette MT, Delfau-Larue MH, Haioun C, Charachon A, Hemery F, Gaulard P, Leroy K, Delchier JC
J Clin Oncol 2005 Aug 1;23(22):5061-6
PMID 16051953
Clinical impact of genetic aberrations in gastric MALT lymphoma: a comprehensive analysis using interphase fluorescence in situ hybridisation
Nakamura S, Ye H, Bacon CM, Goatly A, Liu H, Banham AH, Ventura R, Matsumoto T, Iida M, Ohji Y, Yao T, Tsuneyoshi M, Du MQ
Gut 2007 Oct;56(10):1358-63
PMID 17525089
Chromosome instability and translocation t(11;18) in primary gastric marginal zone B-cell lymphoma of MALT-type
Tibiletti MG, Milani K, Martin V, Zucca E, Motta T, Cortelazzo S, Pinotti G, Mazzucchelli L, Pruneri G, Martinelli G, Barbazza R, Capella C, Bertoni F; International Extranodal Lymphoma Study Group (IELSG)
Hematol Oncol 2007 Dec;25(4):184-8
PMID 17607663
t(11;18)(q21;q21) in extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue in stomach: a study of 48 cases
Wang G, Auerbach A, Wei M, Dow N, Barry TS, Hodge L, Schaffer D, Sobin LH, Aguilera NS
Mod Pathol 2009 Jan;22(1):79-86
PMID 18820661
t(11;18)(q21;q21) translocation as predictive marker for non-responsiveness to salvage thalidomide therapy in patients with marginal zone B-cell lymphoma with gastric involvement
Kuo SH, Cheng AL, Lin CW, Hsu CH, Wu MS, Yeh KH, Tzeng YS, Chen LT
Cancer Chemother Pharmacol 2011 Dec;68(6):1387-95
PMID 21465313

Translocations implicated (Data extracted from papers in the Atlas)

 t(11;18)(q22;q21) BIRC3/MALT1

External links

Mitelman database t(11;18)(q22;q21) [CaseList]     t(11;18)(q22;q21) [Transloc - MCList]   BIRC3/MALT1 Fusion - MCList]
arrayMap arrayMap ((UZH-SIB Zurich)   [auto + random 100 samples .. if exist ]   [tabulated segments]
Disease databaset(11;18)(q22;q21) BIRC3/MALT1
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Feb 14 18:06:50 CET 2019

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us