t(16;20)(p11;q13) FUS/NFATC2

0000-00-00   Jean-Loup Huret , Philippe Dessen 

(Note: the fusion was discovered by NGS. Many chromosome rearrangement mechanisms such as translocation, inversion,deletion or complex rearrangement may lead to the same fusion)

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to u00a0How to contribute

Summary

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to  How to contribute

Genes Involved and Proteins

Gene name

Location

16p11.2

Gene name

Location

20q13.2

Highly cited references

Pubmed IDYearTitleCitations
294311832018Transcriptomic definition of molecular subgroups of small round cell sarcomas.62
323620122020The clinical heterogeneity of round cell sarcomas with EWSR1/FUS gene fusions: Impact of gene fusion type on clinical features and outcome.10
310490202019EWSR1-NFATC2 and FUS-NFATC2 Gene Fusion-Associated Mesenchymal Tumors: Clinicopathologic Correlation and Literature Review.9
310785632019EWSR1/FUS-NFATc2 rearranged round cell sarcoma: clinicopathological series of 4 cases and literature review.7
323277002020NFATc2-rearranged sarcomas: clinicopathologic, molecular, and cytogenetic study of 7 cases with evidence of AGGRECAN as a novel diagnostic marker.5
319725962020NKX3-1 Is a Useful Immunohistochemical Marker of EWSR1-NFATC2 Sarcoma and Mesenchymal Chondrosarcoma.5
333160982021Identification of EWSR1-NFATC2 fusion in simple bone cysts.3
329913392020FUS-NFATC2 or EWSR1-NFATC2 Fusions Are Present in a Large Proportion of Simple Bone Cysts.3
340810362021Expanding the Spectrum of EWSR1-NFATC2-rearranged Benign Tumors: A Common Genomic Abnormality in Vascular Malformation/Hemangioma and Simple Bone Cyst.1
340893792021The role of molecular diagnostics in aneurysmal and simple bone cysts - a prospective analysis of 19 lesions.0
343440772021[Clinicopathological and molecular features of small round cell sarcoma of bone and soft tissue: a study of 72 cases].0

Bibliography

Pubmed IDLast YearTitleAuthors
250102052014The genomic landscape of the Ewing Sarcoma family of tumors reveals recurrent STAG2 mutation.Brohl AS et al

Citation

Jean-Loup Huret ; Philippe Dessen

t(16;20)(p11;q13) FUS/NFATC2

Atlas Genet Cytogenet Oncol Haematol. 0000-00-00

Online version: http://atlasgeneticsoncology.org/solid-tumor/102274/t(16;20)(p11;q13)-fus-nfatc2