| Mutational activation of the K-ras oncogene. A possible pathogenetic factor in adenocarcinoma of the lung. |
| Rodenhuis S, van de Wetering ML, Mooi WJ, Evers SG, van Zandwijk N, Bos JL |
| The New England journal of medicine. 1987 ; 317 (15) : 929-935. |
| PMID 3041218 |
| |
| A genetic model for colorectal tumorigenesis. |
| Fearon ER, Vogelstein B |
| Cell. 1990 ; 61 (5) : 759-767. |
| PMID 2188735 |
| |
| p53 mutations in colorectal cancer. |
| Rodrigues NR, Rowan A, Smith ME, Kerr IB, Bodmer WF, Gannon JV, Lane DP |
| Proceedings of the National Academy of Sciences of the United States of America. 1990 ; 87 (19) : 7555-7559. |
| PMID 1699228 |
| |
| Identification of deletion mutations and three new genes at the familial polyposis locus. |
| Joslyn G, Carlson M, Thliveris A, Albertsen H, Gelbert L, Samowitz W, Groden J, Stevens J, Spirio L, Robertson M |
| Cell. 1991 ; 66 (3) : 601-613. |
| PMID 1678319 |
| |
| Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas. |
| Cottrell S, Bicknell D, Kaklamanis L, Bodmer WF |
| Lancet. 1992 ; 340 (8820) : 626-630. |
| PMID 1355210 |
| |
| Detection of a rare point mutation in Ki-ras of a human bladder cancer xenograft by polymerase chain reaction and direct sequencing. |
| Grimmond SM, Raghavan D, Russell PJ |
| Urological research. 1992 ; 20 (2) : 121-126. |
| PMID 1553789 |
| |
| Genetic changes of both p53 alleles associated with the conversion from colorectal adenoma to early carcinoma in familial adenomatous polyposis and non-familial adenomatous polyposis patients. |
| Kikuchi-Yanoshita R, Konishi M, Ito S, Seki M, Tanaka K, Maeda Y, Iino H, Fukayama M, Koike M, Mori T |
| Cancer research. 1992 ; 52 (14) : 3965-3971. |
| PMID 1319835 |
| |
| Cancer. p53, guardian of the genome. |
| Lane DP |
| Nature. 1992 ; 358 (6381) : 15-16. |
| PMID 1614522 |
| |
| Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. |
| Miyoshi Y, Nagase H, Ando H, Horii A, Ichii S, Nakatsuru S, Aoki T, Miki Y, Mori T, Nakamura Y |
| Human molecular genetics. 1992 ; 1 (4) : 229-233. |
| PMID 1338904 |
| |
| APC mutations occur early during colorectal tumorigenesis. |
| Powell SM, Zilz N, Beazer-Barclay Y, Bryan TM, Hamilton SR, Thibodeau SN, Vogelstein B, Kinzler KW |
| Nature. 1992 ; 359 (6392) : 235-237. |
| PMID 1528264 |
| |
| Microsatellite instability in cancer of the proximal colon. |
| Thibodeau SN, Bren G, Schaid D |
| Science (New York, N.Y.). 1993 ; 260 (5109) : 816-819. |
| PMID 8484122 |
| |
| Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. |
| Bronner CE, Baker SM, Morrison PT, Warren G, Smith LG, Lescoe MK, Kane M, Earabino C, Lipford J, Lindblom A |
| Nature. 1994 ; 368 (6468) : 258-261. |
| PMID 8145827 |
| |
| The DCC gene: structural analysis and mutations in colorectal carcinomas. |
| Cho KR, Oliner JD, Simons JW, Hedrick L, Fearon ER, Preisinger AC, Hedge P, Silverman GA, Vogelstein B |
| Genomics. 1994 ; 19 (3) : 525-531. |
| PMID 8188295 |
| |
| Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. |
| Nicolaides NC, Papadopoulos N, Liu B, Wei YF, Carter KC, Ruben SM, Rosen CA, Haseltine WA, Fleischmann RD, Fraser CM |
| Nature. 1994 ; 371 (6492) : 75-80. |
| PMID 8072530 |
| |
| Mutation of a mutL homolog in hereditary colon cancer. |
| Papadopoulos N, Nicolaides NC, Wei YF, Ruben SM, Carter KC, Rosen CA, Haseltine WA, Fleischmann RD, Fraser CM, Adams MD |
| Science (New York, N.Y.). 1994 ; 263 (5153) : 1625-1629. |
| PMID 8128251 |
| |
| Molecular, cytogenetic, and phenotypic studies of a constitutional reciprocal translocation t(5;10)(q22;q25) responsible for familial adenomatous polyposis in a Dutch pedigree. |
| van der Luijt RB, Tops CM, Khan PM, van der Klift HM, Breukel C, van Leeuwen-Cornelisse IS, Dauwerse HG, Beverstock GC, van Noort E, Snel P |
| Genes, chromosomes & cancer. 1995 ; 13 (3) : 192-202. |
| PMID 7669739 |
| |
| Attenuated familial adenomatous polyposis (AFAP). A phenotypically and genotypically distinctive variant of FAP. |
| Lynch HT, Smyrk T, McGinn T, Lanspa S, Cavalieri J, Lynch J, Slominski-Castor S, Cayouette MC, Priluck I, Luce MC |
| Cancer. 1995 ; 76 (12) : 2427-2433. |
| PMID 8625067 |
| |
| Mutations of GTBP in genetically unstable cells. |
| Papadopoulos N, Nicolaides NC, Liu B, Parsons R, Lengauer C, Palombo F, D'Arrigo A, Markowitz S, Willson JK, Kinzler KW |
| Science (New York, N.Y.). 1995 ; 268 (5219) : 1915-1917. |
| PMID 7604266 |
| |
| Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients. |
| Liu B, Parsons R, Papadopoulos N, Nicolaides NC, Lynch HT, Watson P, Jass JR, Dunlop M, Wyllie A, Peltom§ki P, de la Chapelle A, Hamilton SR, Vogelstein B, Kinzler KW |
| Nature medicine. 1996 ; 2 (2) : 169-174. |
| PMID 8574961 |
| |
| Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers. |
| Thiagalingam S, Lengauer C, Leach FS, Schutte M, Hahn SA, Overhauser J, Willson JK, Markowitz S, Hamilton SR, Kern SE, Kinzler KW, Vogelstein B |
| Nature genetics. 1996 ; 13 (3) : 343-346. |
| PMID 8673134 |
| |
| [p53 and colorectal cancer] |
| Hamelin R, Laurent-Puig P |
| Pathologie-biologie. 1997 ; 45 (10) : 876-881. |
| PMID 9769952 |
| |
| Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis. |
| Hemminki A, Tomlinson I, Markie D, J§rvinen H, Sistonen P, Bjrkqvist AM, Knuutila S, Salovaara R, Bodmer W, Shibata D, de la Chapelle A, Aaltonen LA |
| Nature genetics. 1997 ; 15 (1) : 87-90. |
| PMID 8988175 |
| |
| Alternative genetic pathways in colorectal carcinogenesis. |
| Olschwang S, Hamelin R, Laurent-Puig P, Thuille B, De Rycke Y, Li YJ, Muzeau F, Girodet J, Salmon RJ, Thomas G |
| Proceedings of the National Academy of Sciences of the United States of America. 1997 ; 94 (22) : 12122-12127. |
| PMID 9342373 |
| |
| A gene for familial juvenile polyposis maps to chromosome 18q21.1. |
| Howe JR, Ringold JC, Summers RW, Mitros FA, Nishimura DY, Stone EM |
| American journal of human genetics. 1998 ; 62 (5) : 1129-1136. |
| PMID 9545410 |
| |
| Mutations in the SMAD4/DPC4 gene in juvenile polyposis. |
| Howe JR, Roth S, Ringold JC, Summers RW, J§rvinen HJ, Sistonen P, Tomlinson IP, Houlston RS, Bevan S, Mitros FA, Stone EM, Aaltonen LA |
| Science (New York, N.Y.). 1998 ; 280 (5366) : 1086-1088. |
| PMID 9582123 |
| |
| Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. |
| Jenne DE, Reimann H, Nezu J, Friedel W, Loff S, Jeschke R, Mºller O, Back W, Zimmer M |
| Nature genetics. 1998 ; 18 (1) : 38-43. |
| PMID 9425897 |
| |
| Landscaping the cancer terrain. |
| Kinzler KW, Vogelstein B |
| Science (New York, N.Y.). 1998 ; 280 (5366) : 1036-1037. |
| PMID 9616081 |
| |
| Genetic instabilities in human cancers. |
| Lengauer C, Kinzler KW, Vogelstein B |
| Nature. 1998 ; 396 (6712) : 643-649. |
| PMID 9872311 |
| |
| The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis. |
| Mehlen P, Rabizadeh S, Snipas SJ, Assa-Munt N, Salvesen GS, Bredesen DE |
| Nature. 1998 ; 395 (6704) : 801-804. |
| PMID 9796814 |
| |
| A database of germline p53 mutations in cancer-prone families. |
| Sedlacek Z, Kodet R, Poustka A, Goetz P |
| Nucleic acids research. 1998 ; 26 (1) : 214-215. |
| PMID 9399838 |
| |
| Dominant negative effect of the APC1309 mutation: a possible explanation for genotype-phenotype correlations in familial adenomatous polyposis. |
| Dihlmann S, Gebert J, Siermann A, Herfarth C, von Knebel Doeberitz M |
| Cancer research. 1999 ; 59 (8) : 1857-1860. |
| PMID 10213492 |
| |
| Characterization of newly established colorectal cancer cell lines: correlation between cytogenetic abnormalities and allelic deletions associated with multistep tumorigenesis |
| Gerdes H, Elahi A, Chen Q, Jhanvar S |
| Journal of Genetics. 2000 ; 79 : 113-123. |
| |
| Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling. |
| Liu W, Dong X, Mai M, Seelan RS, Taniguchi K, Krishnadath KK, Halling KC, Cunningham JM, Boardman LA, Qian C, Christensen E, Schmidt SS, Roche PC, Smith DI, Thibodeau SN |
| Nature genetics. 2000 ; 26 (2) : 146-147. |
| PMID 11017067 |
| |
| Somatic mutation of hPMS2 as a possible cause of sporadic human colon cancer with microsatellite instability. |
| Ma AH, Xia L, Littman SJ, Swinler S, Lader G, Polinkovsky A, Olechnowicz J, Kasturi L, Lutterbaugh J, Modrich P, Veigl ML, Markowitz SD, Sedwick WD |
| Oncogene. 2000 ; 19 (18) : 2249-2256. |
| PMID 10822375 |
| |
| Conversion of diploidy to haploidy. |
| Yan H, Papadopoulos N, Marra G, Perrera C, Jiricny J, Boland CR, Lynch HT, Chadwick RB, de la Chapelle A, Berg K, Eshleman JR, Yuan W, Markowitz S, Laken SJ, Lengauer C, Kinzler KW, Vogelstein B |
| Nature. 2000 ; 403 (6771) : 723-724. |
| PMID 10693791 |
| |
| Conversion of diploidy to haploidy. |
| Yan H, Papadopoulos N, Marra G, Perrera C, Jiricny J, Boland CR, Lynch HT, Chadwick RB, de la Chapelle A, Berg K, Eshleman JR, Yuan W, Markowitz S, Laken SJ, Lengauer C, Kinzler KW, Vogelstein B |
| Nature. 2000 ; 403 (6771) : 723-724. |
| PMID 10693791 |
| |
| MSH6 and MSH3 are rarely involved in genetic predisposition to nonpolypotic colon cancer. |
| Huang J, Kuismanen SA, Liu T, Chadwick RB, Johnson CK, Stevens MW, Richards SK, Meek JE, Gao X, Wright FA, Mecklin JP, J§rvinen HJ, Grnberg H, Bisgaard ML, Lindblom A, Peltom§ki P |
| Cancer research. 2001 ; 61 (4) : 1619-1623. |
| PMID 11245474 |
| |
| Different mechanisms in the tumorigenesis of proximal and distal colon cancers. |
| Lindblom A |
| Current opinion in oncology. 2001 ; 13 (1) : 63-69. |
| PMID 11148689 |
| |
| Inherited variants of MYH associated with somatic G:C-->T:A mutations in colorectal tumors. |
| Al-Tassan N, Chmiel NH, Maynard J, Fleming N, Livingston AL, Williams GT, Hodges AK, Davies DR, David SS, Sampson JR, Cheadle JP |
| Nature genetics. 2002 ; 30 (2) : 227-232. |
| PMID 11818965 |
| |
| Chromosome rearrangement with no apparent gene mutation in familial adenomatous polyposis and hepatocellular neoplasia. |
| de Chadar©vian JP, Dunn S, Malatack JJ, Ganguly A, Blecker U, Punnett HH |
| Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. 2002 ; 5 (1) : 69-75. |
| PMID 11815870 |
| |
| Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer. |
| Smith G, Carey FA, Beattie J, Wilkie MJ, Lightfoot TJ, Coxhead J, Garner RC, Steele RJ, Wolf CR |
| Proceedings of the National Academy of Sciences of the United States of America. 2002 ; 99 (14) : 9433-9438. |
| PMID 12093899 |
| |
| Distinct PTEN mutational spectra in hereditary non-polyposis colon cancer syndrome-related endometrial carcinomas compared to sporadic microsatellite unstable tumors. |
| Zhou XP, Kuismanen S, Nystrom-Lahti M, Peltomaki P, Eng C |
| Human molecular genetics. 2002 ; 11 (4) : 445-450. |
| PMID 11854177 |
| |
| Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH. |
| Sieber OM, Lipton L, Crabtree M, Heinimann K, Fidalgo P, Phillips RK, Bisgaard ML, Orntoft TF, Aaltonen LA, Hodgson SV, Thomas HJ, Tomlinson IP |
| The New England journal of medicine. 2003 ; 348 (9) : 791-799. |
| PMID 12606733 |
| |
| Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation status. |
| Oliveira C, Westra JL, Arango D, Ollikainen M, Domingo E, Ferreira A, Velho S, Niessen R, Lagerstedt K, Alhopuro P, Laiho P, Veiga I, Teixeira MR, Ligtenberg M, Kleibeuker JH, Sijmons RH, Plukker JT, Imai K, Lage P, Hamelin R, Albuquerque C, Schwartz S Jr, Lindblom A, Peltomaki P, Yamamoto H, Aaltonen LA, Seruca R, Hofstra RM |
| Human molecular genetics. 2004 ; 13 (19) : 2303-2311. |
| PMID 15294875 |
| |
| Cancer genes and the pathways they control. |
| Vogelstein B, Kinzler KW |
| Nature medicine. 2004 ; 10 (8) : 789-799. |
| PMID 15286780 |
| |
| Germline susceptibility to colorectal cancer due to base-excision repair gene defects. |
| Farrington SM, Tenesa A, Barnetson R, Wiltshire A, Prendergast J, Porteous M, Campbell H, Dunlop MG |
| American journal of human genetics. 2005 ; 77 (1) : 112-119. |
| PMID 15931596 |
| |
| Non-traditional roles for the Adenomatous Polyposis Coli (APC) tumor suppressor protein. |
| Hanson CA, Miller JR |
| Gene. 2005 ; 361 : 1-12. |
| PMID 16185824 |
| |
| Familial mutations in PMS2 can cause autosomal dominant hereditary nonpolyposis colorectal cancer. |
| Worthley DL, Walsh MD, Barker M, Ruszkiewicz A, Bennett G, Phillips K, Suthers G |
| Gastroenterology. 2005 ; 128 (5) : 1431-1436. |
| PMID 15887124 |
| |
| Mapping of hereditary mixed polyposis syndrome (HMPS) to chromosome 10q23 by genomewide high-density single nucleotide polymorphism (SNP) scan and identification of BMPR1A loss of function. |
| Cao X, Eu KW, Kumarasinghe MP, Li HH, Loi C, Cheah PY |
| Journal of medical genetics. 2006 ; 43 (3) : page e13. |
| PMID 16525031 |
| |
| Heterozygous mutations in PMS2 cause hereditary nonpolyposis colorectal carcinoma (Lynch syndrome). |
| Hendriks YM, Jagmohan-Changur S, van der Klift HM, Morreau H, van Puijenbroek M, Tops C, van Os T, Wagner A, Ausems MG, Gomez E, Breuning MH, Brcker-Vriends AH, Vasen HF, Wijnen JT |
| Gastroenterology. 2006 ; 130 (2) : 312-322. |
| PMID 16472587 |
| |
| Adenomatous polyposis coli (APC) differentially regulates beta-catenin phosphorylation and ubiquitination in colon cancer cells. |
| Yang J, Zhang W, Evans PM, Chen X, He X, Liu C |
| The Journal of biological chemistry. 2006 ; 281 (26) : 17751-17757. |
| PMID 16798748 |
| |
| Expansion of the genotypic and phenotypic spectrum in patients with KRAS germline mutations. |
| Zenker M, Lehmann K, Schulz AL, Barth H, Hansmann D, Koenig R, Korinthenberg R, Kreiss-Nachtsheim M, Meinecke P, Morlot S, Mundlos S, Quante AS, Raskin S, Schnabel D, Wehner LE, Kratz CP, Horn D, Kutsche K |
| Journal of medical genetics. 2007 ; 44 (2) : 131-135. |
| PMID 17056636 |
| |