Soft Tissues: Inflammatory myofibroblastic tumor with t(2;17)(p23;q23) CLTC/ALK
2001-08-01 Jean-Loup Huret Affiliation1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Clinics
rare soft tissue tumour found in children and young adults
Pathology
spindle cell proliferation with myofibroblastic differenciation and an inflammatory infiltrate
Prognosis
low malignant potential and good prognosis
Genes Involved and Proteins
Gene name
ALK (anaplastic lymphoma receptor tyrosine kinase)
Location
2p23.2
Protein description
1620 amino acids; 177 kDa; glycoprotein (200 kDa mature protein) ; membrane associated tyrosine kinase receptor
Gene name
CLTC (clathrin heavy polypeptide)
Location
17q23.1
Protein description
1675 amino acids, 191 kDa; mediate endocytosis of transmembrane receptors.
Result of the chromosomal anomaly
Description
5 CLTC - 3 ALK
Description
2196 amino acids. 1634 N-term amino acid from CLTC, containing nearly all of CLTC, including the triskelion assembly domain, fused to the 562 C-term amino acids from ALK (i.e. the entire cytoplasmic portion of ALK with the tyrosine kinase domain).
Highly cited references
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34727172 | 2022 | ALK-positive histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibition. | 79 |
| 19636398 | 2009 | Anaplastic lymphoma kinase-positive large B-cell lymphoma: a distinct clinicopathological entity. | 55 |
| 38014853 | 2024 | Detection of Novel Tyrosine Kinase Fusion Genes as Potential Therapeutic Targets in Bone and Soft Tissue Sarcomas Using DNA/RNA-based Clinical Sequencing. | 50 |
| 35117583 | 2020 | Exome sequencing identified six copy number variations as a prediction model for recurrence of primary prostate cancers with distinctive prognosis. | 46 |
| 22474449 | 2012 | Anaplastic lymphoma kinase-positive large B-cell lymphoma: an underrecognized aggressive lymphoma. | 34 |
| 34141790 | 2021 | Diagnosis and treatment of pediatric anaplastic lymphoma kinase-positive large B-cell lymphoma: A case report. | 27 |
| 21134980 | 2011 | Identification of a novel fusion, SQSTM1-ALK, in ALK-positive large B-cell lymphoma. | 24 |
| 21494621 | 2011 | Inhibition of anaplastic lymphoma kinase (ALK) activity provides a therapeutic approach for CLTC-ALK-positive human diffuse large B cell lymphomas. | 23 |
| 32420302 | 2020 | Central nervous system relapse in a pediatric anaplastic large cell lymphoma patient with CLTC/ALK translocation treated with alectinib: A case report. | 20 |
| 37906510 | 2023 | Acquired resistance to crizotinib in novel CDK14-ALK and CLTC-ALK fusions of ALK-positive large B-cell lymphoma identified by next-generation sequencing. | 17 |
| 21855232 | 2011 | ALK-positive extramedullary plasmacytoma with expression of the CLTC-ALK fusion transcript. | 0 |
| 12920229 | 2003 | ALK+, CD30-, CD20- large B-cell lymphoma containing anaplastic lymphoma kinase (ALK) fused to clathrin heavy chain gene (CLTC). | 0 |
| 24142740 | 2014 | CLTC-ALK fusion as a primary event in congenital blastic plasmacytoid dendritic cell neoplasm. | 0 |
| 38266918 | 2024 | Molecular Screening in Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma: Anaplastic Lymphoma Kinase Analysis, Next-Generation Sequencing Fusion Gene Detection, and T-Cell Receptor Immunoprofiling. | 0 |
| 12750159 | 2003 | ALK activation by the CLTC-ALK fusion is a recurrent event in large B-cell lymphoma. | 0 |
| 39237383 | 2024 | ALK-positive large B-cell lymphoma: a clinicopathological and molecular characteristics analysis of seven cases. | 0 |
| 35164578 | 2022 | Pediatric Non-Myofibroblastic Primitive Spindle Cell Tumors with ALK Gene Rearrangements and Response to Crizotinib. | 0 |
| 12763927 | 2003 | ALK-positive diffuse large B-cell lymphoma is associated with Clathrin-ALK rearrangements: report of 6 cases. | 0 |
| 15208656 | 2004 | Differential effects of X-ALK fusion proteins on proliferation, transformation, and invasion properties of NIH3T3 cells. | 0 |
| 34019866 | 2021 | Identification of novel ALK fusions using DNA/RNA sequencing in immunohistochemistry / RT-PCR discordant NSCLC patients. | 0 |
| 15852431 | 2006 | ALK-positive diffuse large B-cell lymphoma. | 0 |
| 15921012 | 2005 | ALK-positive diffuse large B-cell lymphoma: two more cases and a brief literature review. | 0 |
| 12787312 | 2003 | Inflammatory myofibroblastic tumor with predominant anaplastic lymphoma kinase-positive cells lacking a myofibroblastic phenotype. | 0 |
| 18458503 | 2008 | [Cytomorphology and molecular characterization of CLTC-ALK rearrangement in 2 cases of ALK-positive diffuse large B-cell lymphoma with extensive bone marrow involvement]. | 0 |
| 15492998 | 2004 | ALK-positive diffuse large B-cell lymphoma of the stomach associated with a clathrin-ALK rearrangement. | 0 |
| 12112524 | 2002 | Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor. | 0 |
| 24583837 | 2014 | ALK-positive inflammatory myofibroblastic tumor of the abdomen with widespread microscopic multifocality. | 0 |
| 33154317 | 2020 | Anaplastic Lymphoma Kinase positive large B cell lymphoma of ileocaecal mesentery: A case report. | 0 |
| 23588372 | 2013 | STAT3 pathway is activated in ALK-positive large B-cell lymphoma carrying SQSTM1-ALK rearrangement and provides a possible therapeutic target. | 0 |
| 19521280 | 2009 | ALK-positive diffuse large B-cell lymphoma with the t(2;17)(p23;q23). | 0 |
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 11485898 | 2001 | Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumor. | Bridge JA et al |
| 10383129 | 1999 | Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors. | Griffin CA et al |
| 10934137 | 2000 | Aberrant ALK tyrosine kinase signaling. Different cellular lineages, common oncogenic mechanisms. | Ladanyi M et al |
Citation
Jean-Loup Huret
Soft Tissues: Inflammatory myofibroblastic tumor with t(2;17)(p23;q23) CLTC/ALK
Atlas Genet Cytogenet Oncol Haematol. 2001-08-01
Online version: http://atlasgeneticsoncology.org/solid-tumor/5127/soft-tissues-inflammatory-myofibroblastic-tumor-with-t(2;17)(p23;q23)-cltc-alk
