| Phosphorylation regulates transcriptional activity of PAX3/FKHR and reveals novel therapeutic possibilities. |
| Amstutz R, Wachtel M, Troxler H, Kleinert P, Ebauer M, Haneke T, Oehler-Janne C, Fabbro D, Niggli FK, Schafer BW. |
| Cancer Res. 2008 May 15;68(10):3767-76. |
| PMID 18483260 |
| |
| Detection of the PAX3-FKHR fusion gene in paediatric rhabdomyosarcoma: a reproducible predictor of outcome? |
| Anderson J, Gordon T, McManus A, Mapp T, Gould S, Kelsey A, McDowell H, Pinkerton R, Shipley J, Pritchard-Jones K; UK Children's Cancer Study Group (UKCCSG) and the UK Cancer Cytogenetics Group. |
| Br J Cancer. 2001 Sep 14;85(6):831-5. |
| PMID 11556833 |
| |
| Detection of the t(2;13) chromosomal translocation in alveolar rhabdomyosarcoma using the reverse transcriptase-polymerase chain reaction. |
| Arden KC, Anderson MJ, Finckenstein FG, Czekay S, Cavenee WK. |
| Genes Chromosomes Cancer. 1996 Aug;16(4):254-60. |
| PMID 8875239 |
| |
| Genomic and clinical analyses of 2p24 and 12q13-q14 amplification in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group. |
| Barr FG, Duan F, Smith LM, Gustafson D, Pitts M, Hammond S, Gastier-Foster JM. |
| Genes Chromosomes Cancer. 2009 Aug;48(8):661-72. |
| PMID 19422036 |
| |
| Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma. |
| Barr FG, Galili N, Holick J, Biegel JA, Rovera G, Emanuel BS. |
| Nat Genet. 1993 Feb;3(2):113-7. |
| PMID 8098985 |
| |
| Structural analysis of PAX3 genomic rearrangements in alveolar rhabdomyosarcoma. |
| Barr FG, Nauta LE, Hollows JC. |
| Cancer Genet Cytogenet. 1998 Apr 1;102(1):32-9. |
| PMID 9530337 |
| |
| Examination of gene fusion status in archival samples of alveolar rhabdomyosarcoma entered on the Intergroup Rhabdomyosarcoma Study-III trial: a report from the Children's Oncology Group. |
| Barr FG, Smith LM, Lynch JC, Strzelecki D, Parham DM, Qualman SJ, Breitfeld PP. |
| J Mol Diagn. 2006 May;8(2):202-8. |
| PMID 16645206 |
| |
| A consensus polymerase chain reaction-oligonucleotide hybridization approach for the detection of chromosomal translocations in pediatric bone and soft tissue sarcomas. |
| Barr FG, Xiong QB, Kelly K. |
| Am J Clin Pathol. 1995 Dec;104(6):627-33. |
| PMID 8526204 |
| |
| Gene fusions involving PAX and FOX family members in alveolar rhabdomyosarcoma. |
| Barr FG. |
| Oncogene. 2001 Sep 10;20(40):5736-46. (REVIEW) |
| PMID 11607823 |
| |
| Mechanism for transcriptional gain of function resulting from chromosomal translocation in alveolar rhabdomyosarcoma. |
| Bennicelli JL, Edwards RH, Barr FG. |
| Proc Natl Acad Sci U S A. 1996 May 28;93(11):5455-9. |
| PMID 8643596 |
| |
| Induction of apoptosis in rhabdomyosarcoma cells through down-regulation of PAX proteins. |
| Bernasconi M, Remppis A, Fredericks WJ, Rauscher FJ 3rd, Schafer BW. |
| Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13164-9. |
| PMID 8917562 |
| |
| Detection of the t(2;13)(q35;q14) and PAX3-FKHR fusion in alveolar rhabdomyosarcoma by fluorescence in situ hybridization. |
| Biegel JA, Nycum LM, Valentine V, Barr FG, Shapiro DN. |
| Genes Chromosomes Cancer. 1995 Mar;12(3):186-92. |
| PMID 7536457 |
| |
| The role of Pax genes in the development of tissues and organs: Pax3 and Pax7 regulate muscle progenitor cell functions. |
| Buckingham M, Relaix F. |
| Annu Rev Cell Dev Biol. 2007;23:645-73. (REVIEW) |
| PMID 17506689 |
| |
| Molecular classification of rhabdomyosarcoma--genotypic and phenotypic determinants of diagnosis: a report from the Children's Oncology Group. |
| Davicioni E, Anderson MJ, Finckenstein FG, Lynch JC, Qualman SJ, Shimada H, Schofield DE, Buckley JD, Meyer WH, Sorensen PH, Triche TJ. |
| Am J Pathol. 2009 Feb;174(2):550-64. Epub 2009 Jan 15. |
| PMID 19147825 |
| |
| Fusion genes resulting from alternative chromosomal translocations are overexpressed by gene-specific mechanisms in alveolar rhabdomyosarcoma. |
| Davis RJ, Barr FG. |
| Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):8047-51. |
| PMID 9223312 |
| |
| A specific chromosomal abnormality in rhabdomyosarcoma. |
| Douglass EC, Valentine M, Etcubanas E, Parham D, Webber BL, Houghton PJ, Houghton JA, Green AA. |
| Cytogenet Cell Genet. 1987;45(3-4):148-55. |
| PMID 3691179 |
| |
| Co-expression of alternatively spliced forms of PAX3, PAX7, PAX3-FKHR and PAX7-FKHR with distinct DNA binding and transactivation properties in rhabdomyosarcoma. |
| Du S, Lawrence EJ, Strzelecki D, Rajput P, Xia SJ, Gottesman DM, Barr FG. |
| Int J Cancer. 2005 May 20;115(1):85-92. |
| PMID 15688409 |
| |
| Comparative expression profiling identifies an in vivo target gene signature with TFAP2B as a mediator of the survival function of PAX3/FKHR. |
| Ebauer M, Wachtel M, Niggli FK, Schafer BW. |
| Oncogene. 2007 Nov 8;26(51):7267-81. Epub 2007 May 21. |
| PMID 17525748 |
| |
| Pax3 inhibits myogenic differentiation of cultured myoblast cells. |
| Epstein JA, Lam P, Jepeal L, Maas RL, Shapiro DN. |
| J Biol Chem. 1995 May 19;270(20):11719-22. |
| PMID 7744814 |
| |
| Normal and rearranged PAX3 expression in human rhabdomyosarcoma. |
| Frascella E, Toffolatti L, Rosolen A. |
| Cancer Genet Cytogenet. 1998 Apr 15;102(2):104-9. |
| PMID 9546061 |
| |
| Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma. |
| Galili N, Davis RJ, Fredericks WJ, Mukhopadhyay S, Rauscher FJ 3rd, Emanuel BS, Rovera G, Barr FG. |
| Nat Genet. 1993 Nov;5(3):230-5. |
| PMID 8275086 |
| |
| Cytogenetic abnormalities in 42 rhabdomyosarcoma: a United Kingdom Cancer Cytogenetics Group Study. |
| Gordon T, McManus A, Anderson J, Min T, Swansbury J, Pritchard-Jones K, Shipley J; United kingdom Children's Cancer Study Group; United Kingdom Cancer Cytogenetics Group. |
| Med Pediatr Oncol. 2001 Feb;36(2):259-67. |
| PMID 11452933 |
| |
| FOXO transcription factors at the interface between longevity and tumor suppression. |
| Greer EL, Brunet A. |
| Oncogene. 2005 Nov 14;24(50):7410-25. (REVIEW) |
| PMID 16288288 |
| |
| Human FOX gene family (Review). |
| Katoh M, Katoh M. |
| Int J Oncol. 2004 Nov;25(5):1495-500. (REVIEW) |
| PMID 15492844 |
| |
| Pax3-fkhr and pax7-fkhr fusion genes impact outcome of alveolar rhabdomyosarcoma in children. |
| Kazanowska B, Reich A, Stegmaier S, Bekassy AN, Leuschner I, Chybicka A, Koscielniak E. |
| Fetal Pediatr Pathol. 2007 Jan-Feb;26(1):17-31. |
| PMID 17613043 |
| |
| Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function. |
| Keller C, Arenkiel BR, Coffin CM, El-Bardeesy N, DePinho RA, Capecchi MR. |
| Genes Dev. 2004 Nov 1;18(21):2614-26. Epub 2004 Oct 15. |
| PMID 15489287 |
| |
| cDNA microarrays detect activation of a myogenic transcription program by the PAX3-FKHR fusion oncogene. |
| Khan J, Bittner ML, Saal LH, Teichmann U, Azorsa DO, Gooden GC, Pavan WJ, Trent JM, Meltzer PS. |
| Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13264-9. |
| PMID 10557309 |
| |
| The oncogenic potential of the Pax3-FKHR fusion protein requires the Pax3 homeodomain recognition helix but not the Pax3 paired-box DNA binding domain. |
| Lam PY, Sublett JE, Hollenbach AD, Roussel MF. |
| Mol Cell Biol. 1999 Jan;19(1):594-601. |
| PMID 9858583 |
| |
| Identification of PAX3-FKHR-regulated genes differentially expressed between alveolar and embryonal rhabdomyosarcoma: focus on MYCN as a biologically relevant target. |
| Mercado GE, Xia SJ, Zhang C, Ahn EH, Gustafson DM, Lae M, Ladanyi M, Barr FG. |
| Genes Chromosomes Cancer. 2008 Jun;47(6):510-20. |
| PMID 18335505 |
| |
| Defining the cooperative genetic changes that temporally drive alveolar rhabdomyosarcoma. |
| Naini S, Etheridge KT, Adam SJ, Qualman SJ, Bentley RC, Counter CM, Linardic CM. |
| Cancer Res. 2008 Dec 1;68(23):9583-8. |
| PMID 19047133 |
| |
| Credentialing a preclinical mouse model of alveolar rhabdomyosarcoma. |
| Nishijo K, Chen QR, Zhang L, McCleish AT, Rodriguez A, Cho MJ, Prajapati SI, Gelfond JA, Chisholm GB, Michalek JE, Aronow BJ, Barr FG, Randall RL, Ladanyi M, Qualman SJ, Rubin BP, LeGallo RD, Wang C, Khan J, Keller C. |
| Cancer Res. 2009 Apr 1;69(7):2902-11. |
| PMID 19339268 |
| |
| Use of a novel FISH assay on paraffin-embedded tissues as an adjunct to diagnosis of alveolar rhabdomyosarcoma. |
| Nishio J, Althof PA, Bailey JM, Zhou M, Neff JR, Barr FG, Parham DM, Teot L, Qualman SJ, Bridge JA. |
| Lab Invest. 2006 Jun;86(6):547-56. |
| PMID 16607381 |
| |
| Correlation between histology and PAX/FKHR fusion status in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group. |
| Parham DM, Qualman SJ, Teot L, Barr FG, Morotti R, Sorensen PH, Triche TJ, Meyer WH; Soft Tissue Sarcoma Committee of the Children's Oncology Group. |
| Am J Surg Pathol. 2007 Jun;31(6):895-901. |
| PMID 17527077 |
| |
| The diagnostic potential of the chromosome translocation t(2;13) in rhabdomyosarcoma: a Pcr study of fresh-frozen and paraffin-embedded tumour samples. |
| Reichmuth C, Markus MA, Hillemanns M, Atkinson MJ, Unni KK, Saretzki G, Hofler H. |
| J Pathol. 1996 Sep;180(1):50-7. |
| PMID 8943815 |
| |
| Mouse mesenchymal stem cells expressing PAX-FKHR form alveolar rhabdomyosarcomas by cooperating with secondary mutations. |
| Ren YX, Finckenstein FG, Abdueva DA, Shahbazian V, Chung B, Weinberg KI, Triche TJ, Shimada H, Anderson MJ. |
| Cancer Res. 2008 Aug 15;68(16):6587-97. |
| PMID 18701482 |
| |
| The hybrid PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma transforms fibroblasts in culture. |
| Scheidler S, Fredericks WJ, Rauscher FJ 3rd, Barr FG, Vogt PK. |
| Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9805-9. |
| PMID 8790412 |
| |
| PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology group. |
| Sorensen PH, Lynch JC, Qualman SJ, Tirabosco R, Lim JF, Maurer HM, Bridge JA, Crist WM, Triche TJ, Barr FG. |
| J Clin Oncol. 2002 Jun 1;20(11):2672-9. |
| PMID 12039929 |
| |
| Consistent chromosomal translocation in alveolar rhabdomyosarcoma. |
| Turc-Carel C, Lizard-Nacol S, Justrabo E, Favrot M, Philip T, Tabone E. |
| Cancer Genet Cytogenet. 1986 Jan 15;19(3-4):361-2. |
| PMID 3943053 |
| |
| Gene expression signatures identify rhabdomyosarcoma subtypes and detect a novel t(2;2)(q35;p23) translocation fusing PAX3 to NCOA1. |
| Wachtel M, Dettling M, Koscielniak E, Stegmaier S, Treuner J, Simon-Klingenstein K, Buhlmann P, Niggli FK, Schafer BW. |
| Cancer Res. 2004 Aug 15;64(16):5539-45. |
| PMID 15313887 |
| |
| Chromosomal analysis of sixteen human rhabdomyosarcomas. |
| Wang-Wuu S, Soukup S, Ballard E, Gotwals B, Lampkin B. |
| Cancer Res. 1988 Feb 15;48(4):983-7. |
| PMID 3338090 |
| |
| Cytogenetic studies in subgroups of rhabdomyosarcoma. |
| Whang-Peng J, Knutsen T, Theil K, Horowitz ME, Triche T. |
| Genes Chromosomes Cancer. 1992 Nov;5(4):299-310. |
| PMID 1283318 |
| |
| Analysis of the transforming and growth suppressive activities of the PAX3-FKHR oncoprotein. |
| Xia SJ, Barr FG. |
| Oncogene. 2004 Sep 9;23(41):6864-71. |
| PMID 15286710 |
| |
| High expression of the PAX3-FKHR oncoprotein is required to promote tumorigenesis of human myoblasts. |
| Xia SJ, Holder DD, Pawel BR, Zhang C, Barr FG. |
| Am J Pathol. 2009 Dec;175(6):2600-8. Epub 2009 Nov 5. |
| PMID 19893043 |
| |
| Detection of chimeric transcripts in desmoplastic small round cell tumor and related developmental tumors by reverse transcriptase polymerase chain reaction. A specific diagnostic assay. |
| de Alava E, Ladanyi M, Rosai J, Gerald WL. |
| Am J Pathol. 1995 Dec;147(6):1584-91. |
| PMID 7495283 |
| |
| Regulation of the forkhead transcription factor FKHR, but not the PAX3-FKHR fusion protein, by the serine/threonine kinase Akt. |
| del Peso L, Gonzalez VM, Hernandez R, Barr FG, Nunez G. |
| Oncogene. 1999 Dec 2;18(51):7328-33. |
| PMID 10602488 |
| |
