The rare t(4;12)(q11;p13) in an elderly patient with de novo AML with multilineage dysplasia co-expressing stem cell markers

Sarah Moore, Sanjeev Chunilal, Jacqueline Beerworth  

(1)SA Cancer Cytogenetic Unit, Institute of Medical & veterinary Science, Adelaide, South Australia ; (2)Department of Haematology, The Queen Elizabeth Hospital, Adelaide, South Australia ; e-MAIL sarah.moore@imvs.sa.gov.au

Previous history

Preleukaemia
-
Malignant disease
-
Inborn condition
-

Clinics case report

Age
84 yrs
Sex
F
Liver
-
Spleen
-
Lymph nodes
-
Cns involv
-

Blood data

Wbc
30.2
Hb
11.8
Platelets
189
Bone marrow
20

Cyto path

Cytology
(FAB) M2 with maturation; myeloid/stem cell
Immunophenotype
CD13+, CD33+, CD7+, CD34+, CD117+, HLA-DR+
Rearranged ig tcr
-
Pathology
Numerous mononuclear megakaryocytes. Active erythropoiesis. Active granulopoiesis, hypogranular neutrophils, giant band forms, donut nuclei, pseudo Pelger-Huet anomalies. Blasts have moderate nuclear: cytoplasmic ratio.
Precise diagnosis
de novo AML with multilineage dysplasia

Survival data

Date diagnosis
03-2002
Treatment
Palliative treatment with oral etoposide
Complete remission
-
Treatment relat death
-
Status
D
Date last follow
07-2002
Survival
4

Karyotype

Sample
Bone marrow
Culture time
24
Banding
GTL
Results
46,XX,t(4;12)(q11;p13)[15]/46,XX[5]

Images

Atlas Image
t(4;12)(q11;p13) GTL banded

Comments section

Comments
This elderly woman did not receive induction chemotherapy. Her disease rapidly progressed from a smouldering leukaemia to a florid form. Findings are consistent with previous reports of t(4;12) with stem cell leukaemia in older patients, and with rarity of additional cytogenetic changes.

Bibliography

Pubmed IDLast YearTitleAuthors

Citation

Sarah Moore, Sanjeev Chunilal, Jacqueline Beerworth

The rare t(4;12)(q11;p13) in an elderly patient with de novo AML with multilineage dysplasia co-expressing stem cell markers

Atlas Genet Cytogenet Oncol Haematol. 2002-08-01

Online version: http://atlasgeneticsoncology.org/case-report/208803/js/lib/case-report-explorer/favicon/favicon-32x32.png