Translocation (X;20)(q13;q13.3): a nonrandom abnormality in four patients with myeloid disorders: case 1

Kavita S. Reddy, Kathy Richkind Affiliation

Genzyme Genetics, Orange, CA. Kavita.reddy@gmail.com

Preleukaemia

Malignant disease

Breast infiltrating ductal carcinoma treated with radiation and tamoxifen.

Age

57 yrs

Sex

Liver

Spleen

Lymph nodes

Cns involv

Wbc

3.8

11.4

Platelets

160

Precise diagnosis

Myelodysplastic syndrome (MDS): refractory anaemia

Treatment

Maintenance therapy for MDS patient declined bone marrow transplantation (BMT)

Relapse

Status

Survival

42 +

Sample

Culture time

24/48 unstimulated cultures

Banding

G-banding

Results

46,X,t(X;20)(q13;q13.3)[5]/46,XX[15]

Fig. 1. Partial karyotypes of the translocation t(X;20)(q13;q13.3) for cases 1ï4 (top to bottom). Arrows indicate the derivatives 20 and X.

Pubmed ID	Last Year	Title	Authors
7627929	1995	Characterization by chromosome painting of balanced and unbalanced X chromosome translocations in myelodysplastic syndromes.	Michaux L et al
12606138	2003	Translocation (X;20)(q13.1;q13.3) as a primary chromosomal finding in two patients with myelocytic disorders.	Gray BA et al
15676151	2005	Translocation (X;20)(q13;q13.3): a nonrandom abnormality in four patients with myeloid disorders.	Reddy KS et al

Kavita S. Reddy, Kathy Richkind

Translocation (X;20)(q13;q13.3): a nonrandom abnormality in four patients with myeloid disorders: case 1

Atlas Genet Cytogenet Oncol Haematol. 2005-01-01