Translocation (X;20)(q13;q13.3): a nonrandom abnormality in four patients with myeloid disorders: case 2

Kavita S Reddy, Kathy Richkind  

Genzyme Genetics, Orange, CA. Kavita.reddy@gmail.com

Previous history

Preleukaemia
Myelofibrosis
Malignant disease
A low-grade lobular and ductal carcinoma with a small percentage of intraductal breast disease treated with tamoxifen.

Clinics case report

Age
61 yrs
Sex
F
Liver
-
Spleen
-
Lymph nodes
-
Cns involv
-

Blood data

Wbc
3.05
Hb
8.1
Platelets
62

Cyto path

Precise diagnosis
Myelofibrosis -> acute leukemia

Survival data

Treatment
Induction treatment: topotecan and cytarabine
Relapse
-
Status
A
Survival
55 +

Karyotype

Sample
PB
Culture time
24/48 unstimulated cultures
Banding
G-banding
Results
46,X,t(X;20)(q13;q13.3),der(1;7)(q10;p10)[20]/46,XX[1]

Images

Atlas Image
Fig. 1. Partial karyotypes of the translocation t(X;20)(q13;q13.3) for cases 1ï4 (top to bottom). Arrows indicate the derivatives 20 and X.

Bibliography

Pubmed IDLast YearTitleAuthors
76279391995Biclonal acute monoblastic leukemia showing del(7q) and trisomies 9 and 22.Wong KF et al
126061382003Translocation (X;20)(q13.1;q13.3) as a primary chromosomal finding in two patients with myelocytic disorders.Gray BA et al
156761512005Translocation (X;20)(q13;q13.3): a nonrandom abnormality in four patients with myeloid disorders.Reddy KS et al

Citation

Kavita S Reddy, Kathy Richkind

Translocation (X;20)(q13;q13.3): a nonrandom abnormality in four patients with myeloid disorders: case 2

Atlas Genet Cytogenet Oncol Haematol. 2005-01-01

Online version: http://atlasgeneticsoncology.org/case-report/208808/translocation-(x;20)(q13;q13-3)-a-nonrandom-abnormality-in-four-patients-with-myeloid-disorders-case-2