A new case of t(16;21)(q24;q22) in a secondary AML-M2 following breast cancer therapy

Hélène Bruyère, Wilson Yeung, Peter Tsang  

Department of Pathology and Laboratory Medicine, Vancouver General Hospital, UBC, Canada, Helene.Bruyere@vch.ca and Division of Hematology, Vancouver General Hospital, UBC, Canada

Previous history

Preleukaemia
-
Malignant disease
Breast cancer diagnosed in 2002, treated with radical mastectomy, chemotherapy with cyclophosphamide, epirubicin, 5-fluoro-uracil, radiotherapy.
Inborn condition
-

Clinics case report

Age
61 yrs
Sex
F
Liver
-
Spleen
-
Lymph nodes
-
Cns involv
-

Blood data

Wbc
2.4
Hb
10.7
Platelets
48
Blasts
2
Bone marrow
Neutrophils 0.05 ; Band cells 0.05 ; Metamyelocytes 0.13 ; Myelocytes 0.02 ; Promyelocytes 0.02 ; Blasts 0.51 ; Late normoblasts 0.13 ; Plasma cells 0.01 ; Lymphocytes 0.05 ; Monocytes 0.01 ; Eosinophils 0.02

Cyto path

Cytology
AML-M2
Immunophenotype
Positive for HLA-DR, CD34, CD117, CD13, CD33, MPO, CD56 and CD19 ; Partial Tdt ; Negative for CD7
Precise diagnosis
Hypoplastic AML, therapy related

Survival data

Date diagnosis
04-2005
Treatment
Three cycles of AraC and Danuribicin ; Related bone marrow transplantation planned for September 2005
Complete remission
Yes, 05-2005
Status
A
Date last follow
07-2005
Survival
3 +

Karyotype

Sample
Bone marrow
Culture time
24
Banding
GTG
Results
47,XX,+8,t(16;21)(q24;q22)[13]/46,XX[3]

Images

Atlas Image
Partial karyotype showing the t(16;21) and a +8

Comments section

Comments
All of the nine patients whose treatments were reported (3-9), plus the current case, were treated with a combination of alkylating agents and topoisomerase II inhibitors, +/- radiotherapy.

Article Bibliography

Pubmed IDLast YearTitleAuthors
27583951989Cytogenetics of childhood acute nonlymphocytic leukemia.Raimondi SC et al
78191021994Metaphase fluorescence in situ hybridization (FISH) in the follow-up of 60 patients with haemopoietic malignancies.Nylund SJ et al
80438771994Clonal karyotypic hematopoietic cell abnormalities occurring after autologous bone marrow transplantation for Hodgkin's disease and non-Hodgkin's lymphoma.Traweek ST et al
89320001996Secondary acute myeloblastic leukemia with t(16;21) (q24;q22). involving the AML1 gene.Berger R et al
92167141997A recurrent translocation, t(16;21)(q24;q22), associated with acute myelogenous leukemia: identification by fluorescence in situ hybridization.Shimada M et al
96315851998A case of therapy-related acute myeloblastic leukemia with t(16;21)(q24;q22) after chemotherapy with DNA-topoisomerase II inhibitors, etoposide and mitoxantrone, and the alkylating agent, cyclophosphamide.Takeda K et al
109950192000AML1-MTG16 fusion gene in therapy-related acute leukemia with t(16;21)(q24;q22): two new cases.Salomon-Nguyen F et al
112244962001AML1/MTG16 fusion gene from a t(16;21)(q24;q22) translocation in treatment-induced leukemia after breast cancer.La Starza R et al
119995782002A pediatric case of secondary leukemia associated with t(16;21)(q24;q22) exhibiting the chimeric AML1-MTG16 gene.Kondoh K et al
11921272200221q22 balanced chromosome aberrations in therapy-related hematopoietic disorders: report from an international workshop.Slovak ML et al

Citation

Hélène Bruyère, Wilson Yeung, Peter Tsang

A new case of t(16;21)(q24;q22) in a secondary AML-M2 following breast cancer therapy

Atlas Genet Cytogenet Oncol Haematol. 2005-08-01

Online version: http://atlasgeneticsoncology.org/case-report/208811/js/lib/case-report-explorer/favicon/favicon-16x16.png