MVP (major vault protein)

2000-05-01   Franck Vigué  

Laboratoire de Cytogenetique - Service dHematologie Biologique, Hopital Hotel-Dieu - 75181 Paris Cedex 04, France

Identity

HGNC
MVP
LOCATION
16p11.2
LOCUSID
9961
ALIAS
LRP,VAULT1
FUSION GENES
Show Gene Fusions

DNA/RNA

Transcription

coding sequence, corresponding to full mRNA, is 2840 bp long

Proteins

Description

110 KD protein, 896 amino acids; major cytoplasmic vault protein; vaults are nucleoproteic complexes composed of the MVP associated with two high-molecular weight proteins p240 and p193 which surround a small 140 nucleotides RNA species

Expression

expressed in a variety of human tumor cell lines, the major part being multidrug resistant; expressed also in primary solid tumors, mainly colon carcinoma or ovarian carcinoma, as well as in hematopoietic cancers (myelodysplastic syndrome, acute myeloid or lymphoid leukemia, multiple myeloma); in normal tissues, LRP expression has a wide distribution, with particularly high levels in epithelial cells of the digestive tract

Localisation

cytoplasmic, in the cytosol, with a little fraction (approximately 5%) located in the nuclear membrane and nuclear pores

Function

vault are cytoplasmic organelles which mediate bidirectional nucleocytoplasmic transport of a wide range of substrates, including cytotoxic drugs; vaults would be involved both in vesicule and cytosolic transport of molecules

Homology

104 kD rat MVP

Implicated in

Entity name
implicated in induced multidrug-resistance to anticancer chemotherapy
Disease
it includes resistance to doxorubicin, vinca alkaloids, mitoxantrone and etoposide; the role of LRP by itself in multidrug-resistance is not completely clear because it is only a part of a nucleo-proteic complex involved in macromolecules transport; the introduction and expression of the LRP gene in cells by transfection does not confer a multidrug-resistance phenotype; overexpression of LRP has been associated with poor response to chemotherapy in various types of leukemia and in ovarian carcinoma, however the role of LRP as pronostic factor remains controversial; in multi-resistant cell lines, LRP amplification within a homogeneous staining region is exceptional

Bibliography

Pubmed IDLast YearTitleAuthors

Other Information

Locus ID:

NCBI: 9961
MIM: 605088
HGNC: 7531
Ensembl: ENSG00000013364

Variants:

dbSNP: 9961
ClinVar: 9961
TCGA: ENSG00000013364
COSMIC: MVP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000013364ENST00000357402Q14764
ENSG00000013364ENST00000357402X5D2M8
ENSG00000013364ENST00000395353Q14764
ENSG00000013364ENST00000395353X5D2M8
ENSG00000013364ENST00000562463H3BUP3
ENSG00000013364ENST00000563123I3L155
ENSG00000013364ENST00000563558H3BNF6
ENSG00000013364ENST00000563915H3BQK6
ENSG00000013364ENST00000565164H3BNF2
ENSG00000013364ENST00000566066H3BP76
ENSG00000013364ENST00000566252H3BUK7
ENSG00000013364ENST00000566859H3BQE7
ENSG00000013364ENST00000569887H3BPZ2
ENSG00000013364ENST00000570234H3BRL2
ENSG00000013364ENST00000629059H3BPZ2

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382646422023Major vault protein regulates tumor-associated macrophage polarization through interaction with signal transducer and activator of transcription 6.1
382646422023Major vault protein regulates tumor-associated macrophage polarization through interaction with signal transducer and activator of transcription 6.1
328944372021Y-box binding protein 1 (YB-1) promotes gefitinib resistance in lung adenocarcinoma cells by activating AKT signaling and epithelial-mesenchymal transition through targeting major vault protein (MVP).7
336093622021Proteomic analyses identify major vault protein as a prognostic biomarker for fatal prostate cancer.9
336379722021Constitutive GLI1 expression in chondrosarcoma is regulated by major vault protein via mTOR/S6K1 signaling cascade.10
348299992021MVP Expression Facilitates Tumor Cell Proliferation and Migration Supporting the Metastasis of Colorectal Cancer Cells.4
328944372021Y-box binding protein 1 (YB-1) promotes gefitinib resistance in lung adenocarcinoma cells by activating AKT signaling and epithelial-mesenchymal transition through targeting major vault protein (MVP).7
336093622021Proteomic analyses identify major vault protein as a prognostic biomarker for fatal prostate cancer.9
336379722021Constitutive GLI1 expression in chondrosarcoma is regulated by major vault protein via mTOR/S6K1 signaling cascade.10
348299992021MVP Expression Facilitates Tumor Cell Proliferation and Migration Supporting the Metastasis of Colorectal Cancer Cells.4
300829092019Immunoregulatory protein B7-H3 regulates cancer stem cell enrichment and drug resistance through MVP-mediated MEK activation.45
303361972019Major vault protein is a direct target of Notch1 signaling and contributes to chemoresistance in triple-negative breast cancer cells.30
306548242019Adipocytes promote breast cancer resistance to chemotherapy, a process amplified by obesity: role of the major vault protein (MVP).59
306749432019Lung resistance-related protein (LRP) predicts favorable therapeutic outcome in Acute Myeloid Leukemia.4
309962482019Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK-NF-κB signaling mediated inflammation.42

Citation

Franck Vigué

MVP (major vault protein)

Atlas Genet Cytogenet Oncol Haematol. 2000-05-01

Online version: http://atlasgeneticsoncology.org/gene/120/teaching-explorer/gene-fusions/css/lib/bootstrap.min.css