RAD51 (RAD51 recombinase)

2003-02-01  

Identity

HGNC
RAD51
LOCATION
15q15.1
LOCUSID
5888
ALIAS
BRCC5,FANCR,HRAD51,HsRad51,HsT16930,MRMV2,RAD51A,RECA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5888
MIM: 179617
HGNC: 9817
Ensembl: ENSG00000051180

Variants:

dbSNP: 5888
ClinVar: 5888
TCGA: ENSG00000051180
COSMIC: RAD51

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000051180ENST00000267868Q06609
ENSG00000051180ENST00000382643Q06609
ENSG00000051180ENST00000423169Q06609
ENSG00000051180ENST00000525066E9PJ30
ENSG00000051180ENST00000526763Q9NZG9
ENSG00000051180ENST00000527860E9PNT5
ENSG00000051180ENST00000531277E9PI54
ENSG00000051180ENST00000532743Q06609
ENSG00000051180ENST00000533741H0YD61
ENSG00000051180ENST00000557850Q06609
ENSG00000051180ENST00000645673Q06609

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Homologous recombinationKEGGko03440
Pancreatic cancerKEGGko05212
Homologous recombinationKEGGhsa03440
Pathways in cancerKEGGhsa05200
Pancreatic cancerKEGGhsa05212
Fanconi anemia pathwayKEGGko03460
Fanconi anemia pathwayKEGGhsa03460
Cell CycleREACTOMER-HSA-1640170
MeiosisREACTOMER-HSA-1500620
Meiotic recombinationREACTOMER-HSA-912446
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
HDR through Homologous Recombination (HRR)REACTOMER-HSA-5685942
Homologous DNA Pairing and Strand ExchangeREACTOMER-HSA-5693579
Presynaptic phase of homologous DNA pairing and strand exchangeREACTOMER-HSA-5693616
Resolution of D-Loop StructuresREACTOMER-HSA-5693537
Resolution of D-loop Structures through Holliday Junction IntermediatesREACTOMER-HSA-5693568
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)REACTOMER-HSA-5693554
HDR through Single Strand Annealing (SSA)REACTOMER-HSA-5685938

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
thymus
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
375634672024RAD51 and Infertility: A Review and Case-Control Study.0
380632322024Differential impact of cytoplasmic vs. nuclear RAD51 expression on breast cancer progression and patient prognosis.0
380816412024Human RAD52 stimulates the RAD51-mediated homology search.1
381425952024Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication.2
382619722024Trans-complementation by the RecB nuclease domain of RecBCD enzyme reveals new insight into RecA loading upon χ recognition.2
382868052024FLIP(C1orf112)-FIGNL1 complex regulates RAD51 chromatin association to promote viability after replication stress.1
383341412024Association between polymorphisms of the DNA repair genes RAD51 and OGG1 and risk of cardiovascular disease.0
383609962024RAD51 restricts DNA over-replication from re-activated origins.0
383721162024Comparative study on the expression of Pax3, Rad51 and VEGF-C in esophageal gastric junction adenocarcinoma and distal gastric adenocarcinoma.0
384422362024ATR signaling controls the bystander responses of human chondrosarcoma cells by promoting RAD51-dependent DNA repair.0
384590112024GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer.0
385093612024Cryo-EM structures of RAD51 assembled on nucleosomes containing a DSB site.1
385976692024Human AAA+ ATPase FIGNL1 suppresses RAD51-mediated ultra-fine bridge formation.1
386124442024Human Rad51 Protein Requires Higher Concentrations of Calcium Ions for D-Loop Formation than for Oligonucleotide Strand Exchange.0
375634672024RAD51 and Infertility: A Review and Case-Control Study.0

Citation

Dessen P

RAD51 (RAD51 recombinase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/150/gene-fusions-explorer/gene-fusions/haematological-explorer/favicon/favicon-32x32.png