TFF1 (trefoil factor 1)

2000-08-01   Catherine Tomasetto  , Marie-Christine Rio  

I.G.B.M.C, 1, rue Laurent FRIES, BP 163 67404 ILLKIRH, France

Identity

HGNC
TFF1
LOCATION
21q22.3
LOCUSID
7031
ALIAS
BCEI,D21S21,HP1.A,HPS2,pNR-2,pS2
FUSION GENES
Show Gene Fusions

DNA/RNA

Description

5kb gene; 3 exons

Transcription

600bp cDNA; coding sequence: 252 bp

Proteins

Description

84 amino acids, containing a peptide signal; the 60 AA-long mature secreted peptide contains one TFF (TreFoil Factor) domain and one acidic C-terminal domain

Expression

epithelial cells of the stomach surface

Localisation

cytoplasmic

Function

in the maintenance of mucosa integrity; unknown at the molecular level; deficient mice develop antro-pyloric adenoma

Homology

TFF2/SP (spasmolytic peptide) and TFF3/ITF (intestinal trefoil factor)

Implicated in

Disease
overexpressed in estradiol-dependent breast carcinomas; overexpressed in carcinoma of several other organs; loss of expression in half of gastric carcinomas (TFF1 is normally expressed in the stomach)
Prognosis
good prognosis factor, and marker of response to hormonal treatment in breast carcinomas

Bibliography

Pubmed IDLast YearTitleAuthors
23544351990Prediction of relapse and survival in breast cancer patients by pS2 protein status.Foekens JA et al
88241931996Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein.Lefebvre O et al
97397601998The pS2/TFF1 trefoil factor, from basic research to clinical applications.Ribieras S et al
82977411994pS2 and response to adjuvant hormone therapy in primary breast cancer.Spyratos F et al
106111552000pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of mucins.Tomasetto C et al

Other Information

Locus ID:

NCBI: 7031
MIM: 113710
HGNC: 11755
Ensembl: ENSG00000160182

Variants:

dbSNP: 7031
ClinVar: 7031
TCGA: ENSG00000160182
COSMIC: TFF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160182ENST00000291527P04155

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900
1000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
367583492023Study on TFF1 and PALB2 gene variants associated with gastric carcinoma risk in the Chinese Han population.0
374379262023The Transcription Factor RUNX1 Aggravates Hypoxia-Induced Human Retinal Microvascular Endothelial Cell Dysfunction by Negatively Regulating TFF1 Promoter.0
367583492023Study on TFF1 and PALB2 gene variants associated with gastric carcinoma risk in the Chinese Han population.0
374379262023The Transcription Factor RUNX1 Aggravates Hypoxia-Induced Human Retinal Microvascular Endothelial Cell Dysfunction by Negatively Regulating TFF1 Promoter.0
336603362022The trefoil factor family 1 (TFF-1) and 3 (TFF-3) are upregulated in the saliva, gingival crevicular fluid and serum of periodontitis patients.2
342192062022Circ-TFF1 Facilitates Breast Cancer Development via Regulation of miR-338-3p/FGFR1 Axis.6
352797022022Trefoil factor 1 inhibits the development of esophageal adenocarcinoma from Barrett's epithelium.0
353154032022Association between Promotor hypomethylation of TFF1 and Crohn's Disease.0
359876132022Association of functional genetic variants in TFF1 and nephrolithiasis risk in a Chinese population.0
360577542022TFF1 gene single nucleotide polymorphism (rs3761376) and colorectal cancer risk.1
365149822022IFNγ-dependent silencing of TFF1 during Helicobacter pylori infection.1
336603362022The trefoil factor family 1 (TFF-1) and 3 (TFF-3) are upregulated in the saliva, gingival crevicular fluid and serum of periodontitis patients.2
342192062022Circ-TFF1 Facilitates Breast Cancer Development via Regulation of miR-338-3p/FGFR1 Axis.6
352797022022Trefoil factor 1 inhibits the development of esophageal adenocarcinoma from Barrett's epithelium.0
353154032022Association between Promotor hypomethylation of TFF1 and Crohn's Disease.0

Citation

Catherine Tomasetto ; Marie-Christine Rio

TFF1 (trefoil factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2000-08-01

Online version: http://atlasgeneticsoncology.org/gene/201/gene-fusions/js/lib/deep-insight-explorer