TRAF4 (TNF receptor-associated factor 4)

2000-08-01   Catherine H Régnier , Catherine Tomasetto , Marie.Christine Rio 

I.G.B.M.C, 1, rue Laurent FRIES, BP 163 67404 ILLKIRH, France

Identity

HGNC
TRAF4
LOCATION
17q11.2
IMAGE
Atlas Image
LEGEND
TRAF4 (17q11-q12) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.
LOCUSID
9618
ALIAS
CART1,MLN62,RNF83
FUSION GENES
Show Gene Fusions

DNA/RNA

Description

5,5 kb gene; 7 exons

Transcription

2 kb cDNA; coding sequence: 1410 bp

Proteins

Description

470 amino acids; 53 kDa; contains an amino-terminal RING finger domain, a central stretch of six putative Zinc-binding domains (3 CART domains) and a carboxyl-terminal TRAF domain

Expression

epithelial cells; weak ubiquitous expression in adult tissues; stronger expression level in kidney and thymus

Localisation

cytoplasmic; nuclear when overexpressed

Function

putative signal transducer

Homology

to TRAF proteins (Tumor Necrosis Factor Receptor Associated Factor)

Implicated in

Entity name
17q11-q12 gene amplification; found in about 25% of primary breast carcinomas
Prognosis
poor clinical outcome; increase risk of relapse

Bibliography

Pubmed IDLast YearTitleAuthors
97448591998Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death.Arch RH et al
87521521996Two distinct amplified regions at 17q11-q21 involved in human primary breast cancer.Bièche I et al
75927511995Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma.Régnier CH et al
74900691995Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17.Tomasetto C et al

Other Information

Locus ID:

NCBI: 9618
MIM: 602464
HGNC: 12034
Ensembl: ENSG00000076604

Variants:

dbSNP: 9618
ClinVar: 9618
TCGA: ENSG00000076604
COSMIC: TRAF4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000076604ENST00000262395Q9BUZ4
ENSG00000076604ENST00000262395A0A024QZ59
ENSG00000076604ENST00000262396A0A0C4DFM9
ENSG00000076604ENST00000422344C9JJ10
ENSG00000076604ENST00000444415F6SA91
ENSG00000076604ENST00000454852J9JIG0
ENSG00000076604ENST00000473421K7ER49
ENSG00000076604ENST00000475329J3QS94
ENSG00000076604ENST00000478021J3QR87
ENSG00000076604ENST00000584944K7EJG7
ENSG00000076604ENST00000586813K7EM06
ENSG00000076604ENST00000618771Q2KJU6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Small cell lung cancerKEGGko05222
Pathways in cancerKEGGhsa05200
Small cell lung cancerKEGGhsa05222
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
239733292013TRAF4 promotes TGF-β receptor signaling and drives breast cancer metastasis.67
263474732015A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4-ERK5 axis.41
241548762013TRAF4 is a critical molecule for Akt activation in lung cancer.37
210975082011A novel motif in the Crohn's disease susceptibility protein, NOD2, allows TRAF4 to down-regulate innate immune responses.31
167996352007TRAF4 overexpression is a common characteristic of human carcinomas.30
226491942012Cutting edge: TNF receptor-associated factor 4 restricts IL-17-mediated pathology and signaling processes.28
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
300158832018Circular RNA‑MTO1 suppresses breast cancer cell viability and reverses monastrol resistance through regulating the TRAF4/Eg5 axis.21
120239632002Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase.20
127889482003Identification and characterization of the cytoplasmic protein TRAF4 as a p53-regulated proapoptotic gene.20

Citation

Catherine H Régnier ; Catherine Tomasetto ; Marie.Christine Rio

TRAF4 (TNF receptor-associated factor 4)

Atlas Genet Cytogenet Oncol Haematol. 2000-08-01

Online version: http://atlasgeneticsoncology.org/gene/204/traf4