GSN (gelsolin)

2003-08-01  

Identity

HGNC
LOCATION
9q33.2
LOCUSID
ALIAS
ADF,AGEL
FUSION GENES

Other Information

Locus ID:

NCBI: 2934
MIM: 137350
HGNC: 4620
Ensembl: ENSG00000148180

Variants:

dbSNP: 2934
ClinVar: 2934
TCGA: ENSG00000148180
COSMIC: GSN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148180ENST00000373806Q5T0H8
ENSG00000148180ENST00000373808P06396
ENSG00000148180ENST00000373818P06396
ENSG00000148180ENST00000373818A0A384MEF1
ENSG00000148180ENST00000373823P06396
ENSG00000148180ENST00000394353A0A0A0MS51
ENSG00000148180ENST00000432226Q5T0I0
ENSG00000148180ENST00000449733A0A0A0MT01
ENSG00000148180ENST00000477104A0A0U1RQL8
ENSG00000148180ENST00000545652P06396

Expression (GTEx)

0
500
1000
1500
2000
2500

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Regulation of actin cytoskeletonKEGGhsa04810
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Metabolism of proteinsREACTOMER-HSA-392499
Amyloid fiber formationREACTOMER-HSA-977225
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptotic cleavage of cellular proteinsREACTOMER-HSA-111465
Caspase-mediated cleavage of cytoskeletal proteinsREACTOMER-HSA-264870
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
155261662004Gelsolin superfamily proteins: key regulators of cellular functions.119
211073222011Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-box co-receptor.103
228866302012Multifunctional roles of gelsolin in health and diseases.67
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
124605712002The calcium activation of gelsolin: insights from the 3A structure of the G4-G6/actin complex.49
152158962004Structure of the N-terminal half of gelsolin bound to actin: roles in severing, apoptosis and FAF.45
196665122009Ca2+ binding by domain 2 plays a critical role in the activation and stabilization of gelsolin.40
160083442005Inactivation of endotoxin by human plasma gelsolin.35
164758112006Heparin accelerates gelsolin amyloidogenesis.34
126550442003Visualizing the Ca2+-dependent activation of gelsolin by using synchrotron footprinting.30

Citation

Dessen P

GSN (gelsolin)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/206/gsn