TAF15 (TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa)

2000-09-01   Jean-Loup Huret  

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
TAF15
LOCATION
17q12
LOCUSID
8148
ALIAS
Npl3,RBP56,TAF2N,TAFII68
FUSION GENES
Show Gene Fusions

DNA/RNA

Description

spans 37kb; 16 exons

Transcription

2.2 bp mRNA; alternative splicing: two isoforms of cDNAs consisting of 2144 and 2153 bp; coding sequence 1778 bp

Proteins

Description

589 and 592 amino acid, 62 kDa ; comprises a N-term ser, tyr, gln, gly -rich region, followed by a an RNA binding domain and a Cys2/Cys2 finger motif, and repeats in C-term

Expression

wide; in the fetus and in the adult

Localisation

nuclear

Function

single strand DNA/RNA binding protein; part of theTFIID and RNA polymerase II complex of proteins which assemble on the promoter to form a pre-initiation complex (PIC); TFIID is composed of a TATA-box-binding protein (TBP) and a number of TBP-associated factors (TAFIIS); contribute to the activation of transcription

Homology

with EWSR1 and FUS

Mutations

Somatic

overexpression of TAF2N- FLI-1 chimeras in NIH3T3 cells leads to oncogenic transformation

Implicated in

Entity name
extraskeletal myxoid chondrosarcomas with t(9;17)(q22;q11) --> 5 prime TAF15 3 prime TEC
Disease
a rare tumour: 2.3% of soft tissue sarcomas often localized in deep soft tissues of the lower extremities

Breakpoints

Atlas Image

Article Bibliography

Pubmed IDLast YearTitleAuthors
106375111999The N-terminal domain of human TAFII68 displays transactivation and oncogenic properties.Bertolotti A et al
106645842000TBP-associated factors (TAFIIs): multiple, selective transcriptional mediators in common complexes.Green MR et al
97952131998Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes.Morohoshi F et al
106025191999Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with translocation t(9;17)(q22;q11).Panagopoulos I et al
79357651994Yeast TAFIIS in a multisubunit complex required for activated transcription.Reese JC et al
105372741999Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma.Sjögren H et al

Other Information

Locus ID:

NCBI: 8148
MIM: 601574
HGNC: 11547
Ensembl: ENSG00000270647

Variants:

dbSNP: 8148
ClinVar: 8148
TCGA: ENSG00000270647
COSMIC: TAF15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000270647ENST00000603393A0A075B7E4
ENSG00000270647ENST00000603427A0A075B7D6
ENSG00000270647ENST00000603777A0A075B7D9
ENSG00000270647ENST00000603967A0A075B7C1
ENSG00000270647ENST00000604694A0A075B7F4
ENSG00000270647ENST00000604841Q92804
ENSG00000270647ENST00000604879A0A075B7F2
ENSG00000270647ENST00000605844Q92804

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Basal transcription factorsKEGGko03022
Basal transcription factorsKEGGhsa03022
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380576612024TAF15 amyloid filaments in frontotemporal lobar degeneration.5
382268412024circRNA TATA-box binding protein associated factor 15 acts as an oncogene to facilitate bladder cancer progression through targeting miR-502-5p/high mobility group box 3.2
388111892024circZNF532 promotes endothelial-to-mesenchymal transition in diabetic retinopathy by recruiting TAF15 to stabilize PIK3CD.0
380576612024TAF15 amyloid filaments in frontotemporal lobar degeneration.5
382268412024circRNA TATA-box binding protein associated factor 15 acts as an oncogene to facilitate bladder cancer progression through targeting miR-502-5p/high mobility group box 3.2
388111892024circZNF532 promotes endothelial-to-mesenchymal transition in diabetic retinopathy by recruiting TAF15 to stabilize PIK3CD.0
368950102023CircDNAJC11 interacts with TAF15 to promote breast cancer progression via enhancing MAPK6 expression and activating the MAPK signaling pathway.7
370378642023TAF15 promotes cell proliferation, migration and invasion of gastric cancer via activation of the RAF1/MEK/ERK signalling pathway.2
372578202023m6A-enriched lncRNA LINC00839 promotes tumor progression by enhancing TAF15-mediated transcription of amine oxidase AOC1 in nasopharyngeal carcinoma.6
368950102023CircDNAJC11 interacts with TAF15 to promote breast cancer progression via enhancing MAPK6 expression and activating the MAPK signaling pathway.7
370378642023TAF15 promotes cell proliferation, migration and invasion of gastric cancer via activation of the RAF1/MEK/ERK signalling pathway.2
372578202023m6A-enriched lncRNA LINC00839 promotes tumor progression by enhancing TAF15-mediated transcription of amine oxidase AOC1 in nasopharyngeal carcinoma.6
352286602022LncRNA LINC00649 recruits TAF15 and enhances MAPK6 expression to promote the development of lung squamous cell carcinoma via activating MAPK signaling pathway.11
356436292022The SGYS motif of TAF15 prion-like domain is critical to amyloid fibril formation.2
352286602022LncRNA LINC00649 recruits TAF15 and enhances MAPK6 expression to promote the development of lung squamous cell carcinoma via activating MAPK signaling pathway.11

Citation

Jean-Loup Huret

TAF15 (TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa)

Atlas Genet Cytogenet Oncol Haematol. 2000-09-01

Online version: http://atlasgeneticsoncology.org/gene/256/img/teaching-explorer/js/web-card-_common.js