GAS7 (growth arrest-specific 7)

2000-06-01   Jean-Loup Huret  

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
GAS7
LOCATION
17p13.1
IMAGE
Atlas Image
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
8522
ALIAS
-
FUSION GENES
Show Gene Fusions

DNA/RNA

Description

genomic sequence 167 kb; 14 exons

Transcription

8 kb mRNA; various splicings in the mouse

Proteins

Description

412 aa

Expression

in quiescent/terminally differenciated cells, like other GAS (herien the name Growth Arrest-Specific); selective expression in growth-arrested fibroblasts; GAS7 is predominantly expressed in the brain (in particular, in the mouse, in Purkinje cells of the cerebellum, at lower level in other tissues such as the heart and the testes); gas7 expression is associated with neurite formation (and overproduction of gas7 in neuroblastoma cells promotes neurite-like outgrowth) which suggests that GAS7 may have a role in promoting, and possibly maintaining, maturation and morphological differentiation of cerebellar neurons

Implicated in

Entity name
treatment-related acute non lymphocytic leukemia with t(11;17)(q23;p13)
Disease
only one case: a 13-year-old boy, with a M4 AML and a karyotype with an apparent del(11)(q23) (finally proved to be in reality a cryptic t(11;17)(q23;p13)); four months later the patient died; other cases of t(11;17)(q23;p13) have been described but the involvement of GAS7 has not been proved
Hybrid gene
5 MLL-3 GAS7; breakpoint in MLL intron 8, in MLL bcr; GAS7 breakpoint upstream of exon 1; fusion of mLL exon 7 or exon 8 to GAS7 exon 2

Bibliography

Pubmed IDLast YearTitleAuthors
97367521998gas7: A gene expressed preferentially in growth-arrested fibroblasts and terminally differentiated Purkinje neurons affects neurite formation.Ju YT et al
107066192000Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors.Megonigal MD et al

Other Information

Locus ID:

NCBI: 8522
MIM: 603127
HGNC: 4169
Ensembl: ENSG00000007237

Variants:

dbSNP: 8522
ClinVar: 8522
TCGA: ENSG00000007237
COSMIC: GAS7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000007237ENST00000396115A0A0A0MS68
ENSG00000007237ENST00000432992O60861
ENSG00000007237ENST00000578599J3QS26
ENSG00000007237ENST00000580043J3QLH8
ENSG00000007237ENST00000583882J3QR80
ENSG00000007237ENST00000584146J3KS47
ENSG00000007237ENST00000584389J3KTB1

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384299092024Adipose stem cell-derived exosomes promote wound healing by regulating the let-7i-5p/GAS7 axis.0
384299092024Adipose stem cell-derived exosomes promote wound healing by regulating the let-7i-5p/GAS7 axis.0
369080252023Circ_0078607 increases platinum drug sensitivity via miR-196b-5p/GAS7 axis in ovarian cancer.3
377698912023Gas7 attenuates hepatocellular carcinoma progression and chemoresistance through the PI3K/Akt signaling pathway.0
382402482023Single-nucleotide polymorphisms of TLR4 and GAS7 linked to primary open-angle glaucoma among patients of Shenyang, China.0
369080252023Circ_0078607 increases platinum drug sensitivity via miR-196b-5p/GAS7 axis in ovarian cancer.3
377698912023Gas7 attenuates hepatocellular carcinoma progression and chemoresistance through the PI3K/Akt signaling pathway.0
382402482023Single-nucleotide polymorphisms of TLR4 and GAS7 linked to primary open-angle glaucoma among patients of Shenyang, China.0
354009902022Association of ABCA1 (rs2472493) and GAS7 (rs9913911) gene variants with primary open-angle glaucoma in a Brazilian population.3
354009902022Association of ABCA1 (rs2472493) and GAS7 (rs9913911) gene variants with primary open-angle glaucoma in a Brazilian population.3
336027892021GAS7 Deficiency Promotes Metastasis in MYCN-Driven Neuroblastoma.10
336027892021GAS7 Deficiency Promotes Metastasis in MYCN-Driven Neuroblastoma.10
322169672020Growth arrest specific protein 7 inhibits tau fibrillogenesis.4
322169672020Growth arrest specific protein 7 inhibits tau fibrillogenesis.4
312698452019Association of polymorphism rs11656696 in GAS7 with primary open-Angle Glaucoma in a Chinese Population.5

Citation

Jean-Loup Huret

GAS7 (growth arrest-specific 7)

Atlas Genet Cytogenet Oncol Haematol. 2000-06-01

Online version: http://atlasgeneticsoncology.org/gene/257/css/lib/img/js/lib/bootstrap.min.js