GAS7 (growth arrest-specific 7)

2000-06-01   Jean-Loup Huret 

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
LOCATION
17p13.1
IMAGE
Atlas Image
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
ALIAS
-
FUSION GENES

DNA/RNA

Description

genomic sequence 167 kb; 14 exons

Transcription

8 kb mRNA; various splicings in the mouse

Proteins

Description

412 aa

Expression

in quiescent/terminally differenciated cells, like other GAS (herien the name Growth Arrest-Specific); selective expression in growth-arrested fibroblasts; GAS7 is predominantly expressed in the brain (in particular, in the mouse, in Purkinje cells of the cerebellum, at lower level in other tissues such as the heart and the testes); gas7 expression is associated with neurite formation (and overproduction of gas7 in neuroblastoma cells promotes neurite-like outgrowth) which suggests that GAS7 may have a role in promoting, and possibly maintaining, maturation and morphological differentiation of cerebellar neurons

Implicated in

Entity name
treatment-related acute non lymphocytic leukemia with t(11;17)(q23;p13)
Disease
only one case: a 13-year-old boy, with a M4 AML and a karyotype with an apparent del(11)(q23) (finally proved to be in reality a cryptic t(11;17)(q23;p13)); four months later the patient died; other cases of t(11;17)(q23;p13) have been described but the involvement of GAS7 has not been proved
Hybrid gene
5 MLL-3 GAS7; breakpoint in MLL intron 8, in MLL bcr; GAS7 breakpoint upstream of exon 1; fusion of mLL exon 7 or exon 8 to GAS7 exon 2

Bibliography

Pubmed IDLast YearTitleAuthors
97367521998gas7: A gene expressed preferentially in growth-arrested fibroblasts and terminally differentiated Purkinje neurons affects neurite formation.Ju YT et al
107066192000Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors.Megonigal MD et al

Other Information

Locus ID:

NCBI: 8522
MIM: 603127
HGNC: 4169
Ensembl: ENSG00000007237

Variants:

dbSNP: 8522
ClinVar: 8522
TCGA: ENSG00000007237
COSMIC: GAS7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000007237ENST00000396115A0A0A0MS68
ENSG00000007237ENST00000432992O60861
ENSG00000007237ENST00000578599J3QS26
ENSG00000007237ENST00000580043J3QLH8
ENSG00000007237ENST00000583882J3QR80
ENSG00000007237ENST00000584146J3KS47
ENSG00000007237ENST00000584389J3KTB1

Expression (GTEx)

0
50
100
150
200
250
300

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
225706272012Common genetic determinants of intraocular pressure and primary open-angle glaucoma.72
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
198619582010Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk.11
201983152010Association of genetic variants with hemorrhagic stroke in Japanese individuals.11
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
159481472005Human Gas7 isoforms homologous to mouse transcripts differentially induce neurite outgrowth.10
241510732013Gas7b (growth arrest specific protein 7b) regulates neuronal cell morphology by enhancing microtubule and actin filament assembly.10
198016712009A novel role for hGas7b in microtubular maintenance: possible implication in tau-associated pathology in Alzheimer disease.9
297066512018Wild-type p53 upregulates an early onset breast cancer-associated gene GAS7 to suppress metastasis via GAS7-CYFIP1-mediated signaling pathway.7

Citation

Jean-Loup Huret

GAS7 (growth arrest-specific 7)

Atlas Genet Cytogenet Oncol Haematol. 2000-06-01

Online version: http://atlasgeneticsoncology.org/gene/257/gas7-(growth-arrest-specific-7)