GDF3 (growth differentiation factor 3)

2003-05-01  

Identity

HGNC
LOCATION
12p13.31
LOCUSID
ALIAS
KFS3,MCOP7,MCOPCB6

Other Information

Locus ID:

NCBI: 9573
MIM: 606522
HGNC: 4218
Ensembl: ENSG00000184344

Variants:

dbSNP: 9573
ClinVar: 9573
TCGA: ENSG00000184344
COSMIC: GDF3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184344ENST00000329913Q9NR23

Expression (GTEx)

0
1
2
3

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
163391882006GDF3, a BMP inhibitor, regulates cell fate in stem cells and early embryos.48
198644922010Mutation of the bone morphogenetic protein GDF3 causes ocular and skeletal anomalies.46
184802592008Growth/differentiation factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesity.41
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
188239712009GDF3 is a BMP inhibitor that can activate Nodal signaling only at very high doses.12
193961482009Testicular mixed germ cell tumors: a morphological and immunohistochemical study using stem cell markers, OCT3/4, SOX2 and GDF3, with emphasis on morphologically difficult-to-classify areas.12
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12
224881702012GDF3 inhibits the growth of breast cancer cells and promotes the apoptosis induced by Taxol.5
229637702012Regulation of human growth and differentiation factor 3 gene expression by NANOG in human embryonic carcinoma NCCIT cells.5

Citation

Dessen P

GDF3 (growth differentiation factor 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/332/gdf3