DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
1998-01-01 Jean-Loup Huret AffiliationGenetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Identity
HGNC
LOCATION
11q22.3
IMAGE
LEGEND
DDX10 (11q22) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.
LOCUSID
ALIAS
Dbp4,HRH-J8
FUSION GENES
DNA/RNA
Description
at least 12 exons; spans more than a 200-kb region
Transcription
alternative splicing; 3.2 and 5.0 kb mRNA
Proteins
Description
contains 2 nuclear localization signals (NLS), a DEAD box (DEAD
for: ASP-GLU_ALA-ASP)
Expression
wide
Localisation
nucleolus (probable)
Function
putative ATP-dependent DEAD box RNA helicase; possible role in
ribosome assembly through rRNA processing
Homology
SPB4 and DRS1 (yeast)
Implicated in
Entity name
Disease
therapy related MDS and AML; de novo AML
Hybrid gene
5 NUP98 - 3 DDX10
Fusion protein
fuses the GLFG repeat domains of NUP98 to the charged amino acids
domain of DDX11
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 9166830 | 1997 | The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10. | Arai Y et al |
| 8660968 | 1996 | A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23. | Savitsky K et al |
Other Information
Locus ID:
NCBI: 1662
MIM: 601235
HGNC: 2735
Ensembl: ENSG00000178105
Variants:
dbSNP: 1662
ClinVar: 1662
TCGA: ENSG00000178105
COSMIC: DDX10
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000178105 | ENST00000322536 | Q13206 |
| ENSG00000178105 | ENST00000526794 | E9PIF2 |
| ENSG00000178105 | ENST00000648124 | A0A3B3ISR7 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33657088 | 2021 | DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of α-synuclein toxicity and oligomerization. | 13 |
| 33973712 | 2021 | DDX10 promotes human lung carcinoma proliferation by U3 small nucleolar ribonucleoprotein IMP4. | 7 |
| 34797290 | 2021 | DDX10 and BYSL as the potential targets of chondrosarcoma and glioma. | 4 |
| 33657088 | 2021 | DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of α-synuclein toxicity and oligomerization. | 13 |
| 33973712 | 2021 | DDX10 promotes human lung carcinoma proliferation by U3 small nucleolar ribonucleoprotein IMP4. | 7 |
| 34797290 | 2021 | DDX10 and BYSL as the potential targets of chondrosarcoma and glioma. | 4 |
| 32519665 | 2020 | [DDX10 promotes AIM2-inflammasome activation by maintaining AIM2 protein stability]. | 0 |
| 32519665 | 2020 | [DDX10 promotes AIM2-inflammasome activation by maintaining AIM2 protein stability]. | 0 |
| 30738579 | 2019 | DDX10 overexpression predicts worse prognosis in osteosarcoma and its deletion prohibits cell activities modulated by MAPK pathway. | 14 |
| 30738579 | 2019 | DDX10 overexpression predicts worse prognosis in osteosarcoma and its deletion prohibits cell activities modulated by MAPK pathway. | 14 |
| 26713367 | 2016 | Epigenetic down-regulated DDX10 promotes cell proliferation through Akt/NF-κB pathway in ovarian cancer. | 15 |
| 26713367 | 2016 | Epigenetic down-regulated DDX10 promotes cell proliferation through Akt/NF-κB pathway in ovarian cancer. | 15 |
| 22360420 | 2012 | Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. | 24 |
| 22360420 | 2012 | Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. | 24 |
| 19332556 | 2009 | A novel small-subunit processome assembly intermediate that contains the U3 snoRNP, nucleolin, RRP5, and DBP4. | 44 |
Citation
Jean-Loup Huret
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
Atlas Genet Cytogenet Oncol Haematol. 1998-01-01
Online version: http://atlasgeneticsoncology.org/gene/35/ang-(angiogenin-ribonuclease-rnase-a-family-5)
