MSN (moesin)

2001-08-01   Jean-Loup Huret 

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
LOCATION
Xq12
IMAGE
Atlas Image
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
ALIAS
moesin (membrane-organising extension spike protein)
FUSION GENES

DNA/RNA

Transcription

3879 bp mRNA with a 1733 bp of coding sequence

Proteins

Description

576 amino acids, 75 kDa; contains in N-term a globular membrane binding domain (band 4.1 like domain (amino acids 57 to 224), known also as the four-point-one/ezrin/radixin/moesin domai, an alpha helix domain, and in C-term a domain which interact with actin filaments

Expression

wide; expressed differentially in microvilli and cell adhesion sites

Function

cytoskeleton protein; binds to the plasma membrane and interacts with actin/myosin; role in cell-cell recognition and signaling

Homology

Ezrin, radixin, moesin are called the ERM proteins; they are members ofthe band 4.1 superfamily

Implicated in

Entity name
Disease
found in a case of ALK+ anaplasic large cell lymphoma
Fusion protein
1005 amino acids, 125 kDa; membrane restricted; ;448 N-term amino acid from MSN, containing the band 4.1 like domain and most of the alpha helix domain, fused to the 557 (instead of the usual 562) C-term amino acids from ALK (i.e. the cytoplasmic portion of ALK with the tyrosine kinase domain).
Oncogenesis
tyrosine kinase activity.

Bibliography

Pubmed IDLast YearTitleAuthors
82271931993Ezrin is concentrated in the apical microvilli of a wide variety of epithelial cells whereas moesin is found primarily in endothelial cells.Berryman M et al
100475171999Regulation of cortical structure by the ezrin-radixin-moesin protein family.Bretscher A et al
97578241998The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane.Chishti AH et al
19242891991Moesin: a member of the protein 4.1-talin-ezrin family of proteins.Lankes WT et al
103224531999ERM proteins in cell adhesion and membrane dynamics.Mangeat P et al
113108342001Molecular characterization of a new ALK translocation involving moesin (MSN-ALK) in anaplastic large cell lymphoma.Tort F et al
105749071999Cortical actin organization: lessons from ERM (ezrin/radixin/moesin) proteins.Tsukita S et al

Other Information

Locus ID:

NCBI: 4478
MIM: 309845
HGNC: 7373
Ensembl: ENSG00000147065

Variants:

dbSNP: 4478
ClinVar: 4478
TCGA: ENSG00000147065
COSMIC: MSN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147065ENST00000360270P26038
ENSG00000147065ENST00000360270V9HWC0
ENSG00000147065ENST00000609672V9GZ54

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Leukocyte transendothelial migrationKEGGko04670
Regulation of actin cytoskeletonKEGGko04810
Tight junctionKEGGhsa04530
Leukocyte transendothelial migrationKEGGhsa04670
Regulation of actin cytoskeletonKEGGhsa04810
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
L1CAM interactionsREACTOMER-HSA-373760
Recycling pathway of L1REACTOMER-HSA-437239

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198900072009Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis.148
199658722010Tumor necrosis factor-alpha regulates transforming growth factor-beta-dependent epithelial-mesenchymal transition by promoting hyaluronan-CD44-moesin interaction.80
220312882011Dynamic actin remodeling during epithelial-mesenchymal transition depends on increased moesin expression.79
172374452007Phosphorylated ERM is responsible for increased T cell polarization, adhesion, and migration in patients with systemic lupus erythematosus.70
169088652006Differential regulation of phagosome maturation in macrophages and dendritic cells mediated by Rho GTPases and ezrin-radixin-moesin (ERM) proteins.68
190662822009Moesin is required for HIV-1-induced CD4-CXCR4 interaction, F-actin redistribution, membrane fusion and viral infection in lymphocytes.62
240375282014MiR-200 can repress breast cancer metastasis through ZEB1-independent but moesin-dependent pathways.59
191247452009Ezrin and moesin function together to promote T cell activation.58
192554422009LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation.58
171707072007Moesin regulates stable microtubule formation and limits retroviral infection in cultured cells.55

Citation

Jean-Loup Huret

MSN (moesin)

Atlas Genet Cytogenet Oncol Haematol. 2001-08-01

Online version: http://atlasgeneticsoncology.org/gene/363/msn-(moesin)