CDC25B (cell division cycle 25B)

2003-02-01  

Identity

HGNC
LOCATION
20p13
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 994
MIM: 116949
HGNC: 1726
Ensembl: ENSG00000101224

Variants:

dbSNP: 994
ClinVar: 994
TCGA: ENSG00000101224
COSMIC: CDC25B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101224ENST00000245960P30305
ENSG00000101224ENST00000340833P30305
ENSG00000101224ENST00000344256B4DIG0
ENSG00000101224ENST00000379598G8JLH2
ENSG00000101224ENST00000439880P30305

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Cell cycleKEGGko04110
Progesterone-mediated oocyte maturationKEGGko04914
MAPK signaling pathwayKEGGhsa04010
Cell cycleKEGGhsa04110
Progesterone-mediated oocyte maturationKEGGhsa04914
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
DNA damage-induced cell cycle checkpointsKEGGhsa_M00691
DNA damage-induced cell cycle checkpointsKEGGM00691
DiseaseREACTOMER-HSA-1643685
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
S PhaseREACTOMER-HSA-69242
Cyclin A:Cdk2-associated events at S phase entryREACTOMER-HSA-69656
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Cyclin A/B1 associated events during G2/M transitionREACTOMER-HSA-69273
Cyclin B2 mediated eventsREACTOMER-HSA-157881
Neurodegenerative DiseasesREACTOMER-HSA-8863678
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease modelsREACTOMER-HSA-8862803

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
151288712004Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition.80
217096692011MicroRNA-148a is down-regulated in human pancreatic ductal adenocarcinomas and regulates cell survival by targeting CDC25B.46
124000062002Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation.37
170031052006CHK1 phosphorylates CDC25B during the cell cycle in the absence of DNA damage.32
186766802008Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.32
160822132005CDC25B phosphorylation by Aurora-A occurs at the G2/M transition and is inhibited by DNA damage.31
193080212009Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.29
196921682010Genetic susceptibility to distinct bladder cancer subphenotypes.25
125693652003Overexpression of Cdc25B, an androgen receptor coactivator, in prostate cancer.24
212429642011Cdc25B is negatively regulated by p53 through Sp1 and NF-Y transcription factors.23

Citation

Dessen P

CDC25B (cell division cycle 25B)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40005/cdc25b-(cell-division-cycle-25b)