CDC25C (cell division cycle 25C)

2003-02-01  

Identity

HGNC
CDC25C
LOCATION
5q31.2
LOCUSID
995
ALIAS
CDC25,PPP1R60
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 995
MIM: 157680
HGNC: 1727
Ensembl: ENSG00000158402

Variants:

dbSNP: 995
ClinVar: 995
TCGA: ENSG00000158402
COSMIC: CDC25C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158402ENST00000323760P30307
ENSG00000158402ENST00000348983P30307
ENSG00000158402ENST00000415130P30307
ENSG00000158402ENST00000503022D6RJC2
ENSG00000158402ENST00000510119D6RD20
ENSG00000158402ENST00000513970P30307
ENSG00000158402ENST00000514017H0Y999
ENSG00000158402ENST00000514555P30307
ENSG00000158402ENST00000648466A0A3B3IT42

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Progesterone-mediated oocyte maturationKEGGko04914
Cell cycleKEGGhsa04110
Progesterone-mediated oocyte maturationKEGGhsa04914
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
DNA damage-induced cell cycle checkpointsKEGGhsa_M00691
Cell cycle - G2/M transitionKEGGhsa_M00693
DNA damage-induced cell cycle checkpointsKEGGM00691
Cell cycle - G2/M transitionKEGGM00693
DiseaseREACTOMER-HSA-1643685
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate PKNsREACTOMER-HSA-5625740
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexREACTOMER-HSA-75035
Activation of ATR in response to replication stressREACTOMER-HSA-176187
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Cyclin A/B1 associated events during G2/M transitionREACTOMER-HSA-69273
Cyclin B2 mediated eventsREACTOMER-HSA-157881
Polo-like kinase mediated eventsREACTOMER-HSA-156711
TP53 Regulates Transcription of Cell Cycle GenesREACTOMER-HSA-6791312
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle ArrestREACTOMER-HSA-6804114
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertainREACTOMER-HSA-6804115
Neurodegenerative DiseasesREACTOMER-HSA-8863678
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease modelsREACTOMER-HSA-8862803

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
118976632002Plk1 promotes nuclear translocation of human Cdc25C during prophase.95
194739632009Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases.61
127667742003Dual phosphorylation controls Cdc25 phosphatases and mitotic entry.59
155743282004DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter.52
119254432002Redox regulation of Cdc25C.50
163567542006The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C.46
173828812007Regulation of Cdc25C by ERK-MAP kinases during the G2/M transition.45
203600072010Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition.43
180568022007Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1.40
286516082017Linc00152 promotes malignant progression of glioma stem cells by regulating miR-103a-3p/FEZF1/CDC25A pathway.35

Citation

Dessen P

CDC25C (cell division cycle 25C)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40006/cdc25c-(cell-division-cycle-25c)