CDC25C (cell division cycle 25C)

2003-02-01  

Identity

HGNC
CDC25C
LOCATION
5q31.2
LOCUSID
995
ALIAS
CDC25,PPP1R60
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 995
MIM: 157680
HGNC: 1727
Ensembl: ENSG00000158402

Variants:

dbSNP: 995
ClinVar: 995
TCGA: ENSG00000158402
COSMIC: CDC25C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158402ENST00000323760P30307
ENSG00000158402ENST00000348983P30307
ENSG00000158402ENST00000415130P30307
ENSG00000158402ENST00000503022D6RJC2
ENSG00000158402ENST00000510119D6RD20
ENSG00000158402ENST00000513970P30307
ENSG00000158402ENST00000514017H0Y999
ENSG00000158402ENST00000514555P30307
ENSG00000158402ENST00000648466A0A3B3IT42

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Progesterone-mediated oocyte maturationKEGGko04914
Cell cycleKEGGhsa04110
Progesterone-mediated oocyte maturationKEGGhsa04914
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
DNA damage-induced cell cycle checkpointsKEGGhsa_M00691
Cell cycle - G2/M transitionKEGGhsa_M00693
DNA damage-induced cell cycle checkpointsKEGGM00691
Cell cycle - G2/M transitionKEGGM00693
DiseaseREACTOMER-HSA-1643685
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate PKNsREACTOMER-HSA-5625740
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexREACTOMER-HSA-75035
Activation of ATR in response to replication stressREACTOMER-HSA-176187
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Cyclin A/B1 associated events during G2/M transitionREACTOMER-HSA-69273
Cyclin B2 mediated eventsREACTOMER-HSA-157881
Polo-like kinase mediated eventsREACTOMER-HSA-156711
TP53 Regulates Transcription of Cell Cycle GenesREACTOMER-HSA-6791312
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle ArrestREACTOMER-HSA-6804114
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertainREACTOMER-HSA-6804115
Neurodegenerative DiseasesREACTOMER-HSA-8863678
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease modelsREACTOMER-HSA-8862803

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
387132522024KIF22 promotes multiple myeloma progression by regulating the CDC25C/CDK1/cyclinB1 pathway.0
387132522024KIF22 promotes multiple myeloma progression by regulating the CDC25C/CDK1/cyclinB1 pathway.0
376827092023PUF60 promotes cell cycle and lung cancer progression by regulating alternative splicing of CDC25C.2
376827092023PUF60 promotes cell cycle and lung cancer progression by regulating alternative splicing of CDC25C.2
329459452022CDC25c expression in patients with myelofibrosis is associated with stronger myeloproliferation and shorter overall survival.0
356159822022CDC25C is a prognostic biomarker and correlated with mitochondrial homeostasis in pancreatic adenocarcinoma.2
329459452022CDC25c expression in patients with myelofibrosis is associated with stronger myeloproliferation and shorter overall survival.0
356159822022CDC25C is a prognostic biomarker and correlated with mitochondrial homeostasis in pancreatic adenocarcinoma.2
331689562021Targeting TOPK sensitises tumour cells to radiation-induced damage by enhancing replication stress.11
337563412021BTNL9 is frequently downregulated and inhibits proliferation and metastasis via the P53/CDC25C and P53/GADD45 pathways in breast cancer.9
342758902021Integrative genome wide analysis of protein tyrosine phosphatases identifies CDC25C as prognostic and predictive marker for chemoresistance in breast cancer.2
345428292021Identification of Prognostic Genes for Colon Cancer through Gene Co-expression Network Analysis.1
331689562021Targeting TOPK sensitises tumour cells to radiation-induced damage by enhancing replication stress.11
337563412021BTNL9 is frequently downregulated and inhibits proliferation and metastasis via the P53/CDC25C and P53/GADD45 pathways in breast cancer.9
342758902021Integrative genome wide analysis of protein tyrosine phosphatases identifies CDC25C as prognostic and predictive marker for chemoresistance in breast cancer.2

Citation

Dessen P

CDC25C (cell division cycle 25C)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40006/css/haematological-explorer/js/web-card-_common.js