CDH2 (cadherin 2)

2003-11-01  

Identity

HGNC
LOCATION
18q12.1
LOCUSID
ALIAS
ACOGS,ARVD14,CD325,CDHN,CDw325,NCAD
FUSION GENES

Other Information

Locus ID:

NCBI: 1000
MIM: 114020
HGNC: 1759
Ensembl: ENSG00000170558

Variants:

dbSNP: 1000
ClinVar: 1000
TCGA: ENSG00000170558
COSMIC: CDH2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170558ENST00000269141P19022
ENSG00000170558ENST00000269141A0A024RC42
ENSG00000170558ENST00000399380P19022
ENSG00000170558ENST00000413878C9JMH2
ENSG00000170558ENST00000418492C9J8J8
ENSG00000170558ENST00000430882C9J126

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGko05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGhsa05412
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-cell junction organizationREACTOMER-HSA-421270
Adherens junctions interactionsREACTOMER-HSA-418990
Developmental BiologyREACTOMER-HSA-1266738
MyogenesisREACTOMER-HSA-525793
CDO in myogenesisREACTOMER-HSA-375170

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA450401methadoneChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
136785862003A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations.182
157137512005Cadherin switching: essential for behavioral but not morphological changes during an epithelium-to-mesenchyme transition.161
123988942002A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor.157
151534302004Cadherin switch in tumor progression.153
213152592011Reelin regulates cadherin function via Dab1/Rap1 to control neuronal migration and lamination in the neocortex.144
152179492004N-cadherin expression and epithelial-mesenchymal transition in pancreatic carcinoma.135
210574942010Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance.127
282189102017A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion.118
200822862010Stem cell shape regulates a chondrogenic versus myogenic fate through Rac1 and N-cadherin.110
183621842008Collagen I-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1.88

Citation

Dessen P

CDH2 (cadherin 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40023/cdh2-(cadherin-2)