CLCA2 (chloride channel accessory 2)

2003-02-01  

Identity

HGNC
CLCA2
LOCATION
1p22.3
LOCUSID
9635
ALIAS
CACC,CACC3,CLCRG2,CaCC-3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9635
MIM: 604003
HGNC: 2016
Ensembl: ENSG00000137975

Variants:

dbSNP: 9635
ClinVar: 9635
TCGA: ENSG00000137975
COSMIC: CLCA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137975ENST00000370565Q9UQC9

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Renin secretionKEGGhsa04924
Renin secretionKEGGko04924
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
219091352012Loss of breast epithelial marker hCLCA2 promotes epithelial-to-mesenchymal transition and indicates higher risk of metastasis.34
126121942003Modulation of Ca2+-activated Cl- secretion by basolateral K+ channels in human normal and cystic fibrosis airway epithelia.32
196543132009hCLCA2 Is a p53-Inducible Inhibitor of Breast Cancer Cell Proliferation.28
229902032012CLCA2, a target of the p53 family, negatively regulates cancer cell migration and invasion.22
194235402009Common variation in genes related to innate immunity and risk of adult glioma.19
255579502015Identification of risk loci for Crohn's disease phenotypes using a genome-wide association study.18
168733622006The putative chloride channel hCLCA2 has a single C-terminal transmembrane segment.16
224319222012CLCA2 as a p53-inducible senescence mediator.14
204069642010Risk of meningioma and common variation in genes related to innate immunity.12
269305812016CLCA2 Interactor EVA1 Is Required for Mammary Epithelial Cell Differentiation.11

Citation

Dessen P

CLCA2 (chloride channel accessory 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40096/clca2-(chloride-channel-accessory-2)