LEF1 (lymphoid enhancer binding factor 1)

2003-02-01  

Identity

HGNC
LOCATION
4q25
LOCUSID
ALIAS
LEF-1,TCF10,TCF1ALPHA,TCF7L3
FUSION GENES

Other Information

Locus ID:

NCBI: 51176
MIM: 153245
HGNC: 6551
Ensembl: ENSG00000138795

Variants:

dbSNP: 51176
ClinVar: 51176
TCGA: ENSG00000138795
COSMIC: LEF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138795ENST00000265165Q9UJU2
ENSG00000138795ENST00000265165A0A024RDI7
ENSG00000138795ENST00000379951Q9UJU2
ENSG00000138795ENST00000438313Q9UJU2
ENSG00000138795ENST00000504950D6RID7
ENSG00000138795ENST00000506680Q9UJU2
ENSG00000138795ENST00000510624Q9UJU2
ENSG00000138795ENST00000512172D6RIV1
ENSG00000138795ENST00000515500D6RAB1

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Adherens junctionKEGGko04520
MelanogenesisKEGGko04916
Colorectal cancerKEGGko05210
Endometrial cancerKEGGko05213
Prostate cancerKEGGko05215
Thyroid cancerKEGGko05216
Basal cell carcinomaKEGGko05217
Acute myeloid leukemiaKEGGko05221
Wnt signaling pathwayKEGGhsa04310
Adherens junctionKEGGhsa04520
MelanogenesisKEGGhsa04916
Pathways in cancerKEGGhsa05200
Colorectal cancerKEGGhsa05210
Endometrial cancerKEGGhsa05213
Prostate cancerKEGGhsa05215
Thyroid cancerKEGGhsa05216
Basal cell carcinomaKEGGhsa05217
Acute myeloid leukemiaKEGGhsa05221
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGko05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGhsa05412
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Wnt signalingKEGGhsa_M00677
Wnt signalingKEGGM00677
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
Degradation of beta-catenin by the destruction complexREACTOMER-HSA-195253
Repression of WNT target genesREACTOMER-HSA-4641265
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Formation of the beta-catenin:TCF transactivating complexREACTOMER-HSA-201722
Binding of TCF/LEF:CTNNB1 to target gene promotersREACTOMER-HSA-4411364
Deactivation of the beta-catenin transactivating complexREACTOMER-HSA-3769402
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
Ca2+ pathwayREACTOMER-HSA-4086398
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
195766242009WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis.228
121614432002Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression.150
120952322002Direct evidence for a role of beta-catenin/LEF-1 signaling pathway in induction of EMT.143
120528222002Wnt-3A/beta-catenin signaling induces transcription from the LEF-1 promoter.92
125564972003Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling.83
125890562003IKKalpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf.68
164241712006Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo.60
157282542005PITX2, beta-catenin and LEF-1 interact to synergistically regulate the LEF-1 promoter.59
205955132010LEF-1 is a prosurvival factor in chronic lymphocytic leukemia and is expressed in the preleukemic state of monoclonal B-cell lymphocytosis.55
170631412006LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia.53

Citation

Dessen P

LEF1 (lymphoid enhancer binding factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/401/lef1