CNOT7 (CCR4-NOT transcription complex subunit 7)

2003-06-01  

Identity

HGNC
CNOT7
LOCATION
8p22
LOCUSID
29883
ALIAS
CAF-1,CAF1,Caf1a,hCAF-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 29883
MIM: 604913
HGNC: 14101
Ensembl: ENSG00000198791

Variants:

dbSNP: 29883
ClinVar: 29883
TCGA: ENSG00000198791
COSMIC: CNOT7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198791ENST00000361272Q9UIV1
ENSG00000198791ENST00000518021E5RGA8
ENSG00000198791ENST00000518541H0YBT3
ENSG00000198791ENST00000519918H0YAV9
ENSG00000198791ENST00000519954E5RHV9
ENSG00000198791ENST00000520178E5RJE0
ENSG00000198791ENST00000523917Q9UIV1
ENSG00000198791ENST00000524358E5RGH2
ENSG00000198791ENST00000628418E5RHV9

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
Deadenylation of mRNAREACTOMER-HSA-429947
TP53 Regulates Transcription of Cell Cycle GenesREACTOMER-HSA-6791312
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertainREACTOMER-HSA-6804115

References

Pubmed IDYearTitleCitations
330214112021Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4-Not deadenylase in non-Hodgkin lymphoma.6
334122132021CNOT7 modulates biological functions of ovarian cancer cells via AKT signaling pathway.4
337575992021Coping with brain amyloid: genetic heterogeneity and cognitive resilience to Alzheimer's pathophysiology.14
340385622021Crystal structure and functional properties of the human CCR4-CAF1 deadenylase complex.10
330214112021Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4-Not deadenylase in non-Hodgkin lymphoma.6
334122132021CNOT7 modulates biological functions of ovarian cancer cells via AKT signaling pathway.4
337575992021Coping with brain amyloid: genetic heterogeneity and cognitive resilience to Alzheimer's pathophysiology.14
340385622021Crystal structure and functional properties of the human CCR4-CAF1 deadenylase complex.10
321604022020CNOT7 depletion reverses natural killer cell resistance by modulating the tumor immune microenvironment of hepatocellular carcinoma.5
321604022020CNOT7 depletion reverses natural killer cell resistance by modulating the tumor immune microenvironment of hepatocellular carcinoma.5
3098454520191-Hydroxy-xanthine derivatives inhibit the human Caf1 nuclease and Caf1-containing nuclease complexes via Mg(2+)-dependent binding.1
311804912019DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity.14
3098454520191-Hydroxy-xanthine derivatives inhibit the human Caf1 nuclease and Caf1-containing nuclease complexes via Mg(2+)-dependent binding.1
311804912019DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity.14
285918692017Alternative splicing of CNOT7 diversifies CCR4-NOT functions.7

Citation

Dessen P

CNOT7 (CCR4-NOT transcription complex subunit 7)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40115/favicon/js/lib/all.min.js