CRABP1 (cellular retinoic acid binding protein 1)

2003-08-01  

Identity

HGNC
LOCATION
15q25.1
LOCUSID
ALIAS
CRABP,CRABP-I,CRABPI,RBP5
FUSION GENES

Other Information

Locus ID:

NCBI: 1381
MIM: 180230
HGNC: 2338
Ensembl: ENSG00000166426

Variants:

dbSNP: 1381
ClinVar: 1381
TCGA: ENSG00000166426
COSMIC: CRABP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166426ENST00000299529P29762
ENSG00000166426ENST00000299529F1T0F7
ENSG00000166426ENST00000406419B5MCB5

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Retinoic AcidREACTOMER-HSA-5362517
RA biosynthesis pathwayREACTOMER-HSA-5365859

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
171671792006ADAMTS1, CRABP1, and NR3C1 identified as epigenetically deregulated genes in colorectal tumorigenesis.52
176230562007DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets.48
126406812003Hypermethylation, but not LOH, is associated with the low expression of MT1G and CRABP1 in papillary thyroid carcinoma.25
261241812015miR-93/miR-106b/miR-375-CIC-CRABP1: a novel regulatory axis in prostate cancer progression.25
180000642007RARalpha-PLZF overcomes PLZF-mediated repression of CRABPI, contributing to retinoid resistance in t(11;17) acute promyelocytic leukemia.23
174385262007Frequent methylation-associated silencing of a candidate tumor-suppressor, CRABP1, in esophageal squamous-cell carcinoma.21
206348912010Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.18
146053202003Elevation of CRABP-I in the cerebrospinal fluid of patients with Moyamoya disease.17
261429052015CRABP1 is associated with a poor prognosis in breast cancer: adding to the complexity of breast cancer cell response to retinoic acid.17
155151572004TIMP1 and SERPIN-A overexpression and TFF3 and CRABP1 underexpression as biomarkers for papillary thyroid carcinoma.14

Citation

Dessen P

CRABP1 (cellular retinoic acid binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40142/crabp1-(cellular-retinoic-acid-binding-protein-1)