CSNK1E (casein kinase 1 epsilon)

2003-11-01  

Identity

HGNC
LOCATION
22q13.1
LOCUSID
ALIAS
CKIe,CKIepsilon,HCKIE
FUSION GENES

Other Information

Locus ID:

NCBI: 1454
MIM: 600863
HGNC: 2453
Ensembl: ENSG00000213923

Variants:

dbSNP: 1454
ClinVar: 1454
TCGA: ENSG00000213923
COSMIC: CSNK1E

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000213923ENST00000359867P49674
ENSG00000213923ENST00000359867Q5U045
ENSG00000213923ENST00000366216H0Y5S9
ENSG00000213923ENST00000396832P49674
ENSG00000213923ENST00000396832Q5U045
ENSG00000213923ENST00000403904P49674
ENSG00000213923ENST00000403904Q5U045
ENSG00000213923ENST00000405675B0QY35
ENSG00000213923ENST00000413574B0QY34
ENSG00000213923ENST00000430335B0QY36
ENSG00000213923ENST00000431611H7C3J2
ENSG00000213923ENST00000431632H0Y682
ENSG00000213923ENST00000442216H7C0Y5
ENSG00000213923ENST00000451964H0Y645

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Hedgehog signaling pathwayKEGGko04340
Circadian rhythmKEGGko04710
Wnt signaling pathwayKEGGhsa04310
Hedgehog signaling pathwayKEGGhsa04340
Circadian rhythmKEGGhsa04710
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
FoxO signaling pathwayKEGGhsa04068
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
WNT mediated activation of DVLREACTOMER-HSA-201688
Gene ExpressionREACTOMER-HSA-74160
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
Circadian ClockREACTOMER-HSA-400253
AURKA Activation by TPX2REACTOMER-HSA-8854518
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
Hippo signaling pathway -multiple speciesKEGGko04392
Hippo signaling pathway -multiple speciesKEGGhsa04392
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA444460Heroin DependenceDiseaseClinicalAnnotationassociatedPD
PA452619heroinChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
200480012010A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP).443
157676832005Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation.166
184001652008Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins.138
159172222005SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein.105
185189252008Genetic susceptibility to heroin addiction: a candidate gene association study.99
198052222009CKIepsilon/delta-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock.94
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
118750632002The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon.91
200721162010Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder.91
165287482006Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder.88

Citation

Dessen P

CSNK1E (casein kinase 1 epsilon)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40170/csnk1e