CSNK1E (casein kinase 1 epsilon)

2003-11-01  

Identity

HGNC
CSNK1E
LOCATION
22q13.1
LOCUSID
1454
ALIAS
CKIe,CKIepsilon,HCKIE
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1454
MIM: 600863
HGNC: 2453
Ensembl: ENSG00000213923

Variants:

dbSNP: 1454
ClinVar: 1454
TCGA: ENSG00000213923
COSMIC: CSNK1E

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000213923ENST00000359867P49674
ENSG00000213923ENST00000359867Q5U045
ENSG00000213923ENST00000366216H0Y5S9
ENSG00000213923ENST00000396832P49674
ENSG00000213923ENST00000396832Q5U045
ENSG00000213923ENST00000403904P49674
ENSG00000213923ENST00000403904Q5U045
ENSG00000213923ENST00000405675B0QY35
ENSG00000213923ENST00000413574B0QY34
ENSG00000213923ENST00000430335B0QY36
ENSG00000213923ENST00000431611H7C3J2
ENSG00000213923ENST00000431632H0Y682
ENSG00000213923ENST00000442216H7C0Y5
ENSG00000213923ENST00000451964H0Y645

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Hedgehog signaling pathwayKEGGko04340
Circadian rhythmKEGGko04710
Wnt signaling pathwayKEGGhsa04310
Hedgehog signaling pathwayKEGGhsa04340
Circadian rhythmKEGGhsa04710
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
FoxO signaling pathwayKEGGhsa04068
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
WNT mediated activation of DVLREACTOMER-HSA-201688
Gene ExpressionREACTOMER-HSA-74160
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
Circadian ClockREACTOMER-HSA-400253
AURKA Activation by TPX2REACTOMER-HSA-8854518
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
Hippo signaling pathway -multiple speciesKEGGko04392
Hippo signaling pathway -multiple speciesKEGGhsa04392
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA444460Heroin DependenceDiseaseClinicalAnnotationassociatedPD
PA452619heroinChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
377879832023CK1ε drives osteogenic differentiation of bone marrow mesenchymal stem cells via activating Wnt/β-catenin pathway.0
377879832023CK1ε drives osteogenic differentiation of bone marrow mesenchymal stem cells via activating Wnt/β-catenin pathway.0
321756352020Casein kinase 1 epsilon facilitates cartilage destruction in osteoarthritis through JNK pathway.5
323219362020CRISPR-mediated gene targeting of CK1δ/ε leads to enhanced understanding of their role in endocytosis via phosphoregulation of GAPVD1.5
328718312020Cytoplasmic CK1ε Protein Expression Is Correlated With Distant Metastasis and Survival in Patients With Melanoma.1
328886472020The Daple-CK1ε complex regulates Dvl2 phosphorylation and canonical Wnt signaling.2
328994342020Novel Insights into the Biochemical Mechanism of CK1ε and its Functional Interplay with DDX3X.0
321756352020Casein kinase 1 epsilon facilitates cartilage destruction in osteoarthritis through JNK pathway.5
323219362020CRISPR-mediated gene targeting of CK1δ/ε leads to enhanced understanding of their role in endocytosis via phosphoregulation of GAPVD1.5
328718312020Cytoplasmic CK1ε Protein Expression Is Correlated With Distant Metastasis and Survival in Patients With Melanoma.1
328886472020The Daple-CK1ε complex regulates Dvl2 phosphorylation and canonical Wnt signaling.2
328994342020Novel Insights into the Biochemical Mechanism of CK1ε and its Functional Interplay with DDX3X.0
304886592019A de novo pathogenic CSNK1E mutation identified by exome sequencing in family trios with epileptic encephalopathy.6
310007032019Dishevelled-3 conformation dynamics analyzed by FRET-based biosensors reveals a key role of casein kinase 1.10
312355882019Long noncoding RNA LINC00673-v4 promotes aggressiveness of lung adenocarcinoma via activating WNT/β-catenin signaling.56

Citation

Dessen P

CSNK1E (casein kinase 1 epsilon)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40170/img/case-report-explorer/gene-fusions-explorer/js/lib/zoomerang.js