CTPS1 (CTP synthase 1)

2003-06-01  

Identity

HGNC
LOCATION
1p34.2
LOCUSID
ALIAS
CTPS,GATD5,GATD5A,IMD24

Other Information

Locus ID:

NCBI: 1503
MIM: 123860
HGNC: 2519
Ensembl: ENSG00000171793

Variants:

dbSNP: 1503
ClinVar: 1503
TCGA: ENSG00000171793
COSMIC: CTPS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171793ENST00000372616P17812
ENSG00000171793ENST00000463285A0A3B3ITF6
ENSG00000171793ENST00000463423A0A3B3ISY3
ENSG00000171793ENST00000470271A0A3B3ITH9
ENSG00000171793ENST00000648020A0A3B3ITB8
ENSG00000171793ENST00000648914A0A3B3IRQ8
ENSG00000171793ENST00000649124P17812
ENSG00000171793ENST00000649215B4E1E0
ENSG00000171793ENST00000649864A0A3B3IRI2
ENSG00000171793ENST00000650070P17812

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Pyrimidine metabolismKEGGko00240
Pyrimidine metabolismKEGGhsa00240
Metabolic pathwaysKEGGhsa01100
Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTPKEGGhsa_M00052
Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTPKEGGM00052
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Synthesis and interconversion of nucleotide di- and triphosphatesREACTOMER-HSA-499943

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
284594472017Human CTP synthase filament structure reveals the active enzyme conformation.36
248702412014CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation.34
244774772014Glutamine deprivation initiates reversible assembly of mammalian rods and rings.27
161793392005Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A.24
174630022007Phosphorylation of human CTP synthetase 1 by protein kinase C: identification of Ser(462) and Thr(455) as major sites of phosphorylation.17
176819422007Regulation of human cytidine triphosphate synthetase 1 by glycogen synthase kinase 3.12
207392752010Regulation of human cytidine triphosphate synthetase 2 by phosphorylation.12
290971812017CTP synthase forms the cytoophidium in human hepatocellular carcinoma.8
186005512008Human cytidine triphosphate synthetase 1 interacting proteins.1

Citation

Dessen P

CTPS1 (CTP synthase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40199/ctps1