CTSG (cathepsin G)

2003-08-01 Affiliation

Identity

HGNC

CTSG

LOCATION

14q12

LOCUSID

1511

ALIAS

CATG,CG

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1511
MIM: 116830
HGNC: 2532
Ensembl: ENSG00000100448

Variants:

dbSNP: 1511
ClinVar: 1511
TCGA: ENSG00000100448
COSMIC: CTSG

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000100448	ENST00000216336	P08311

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Renin-angiotensin system	KEGG	ko04614
Systemic lupus erythematosus	KEGG	ko05322
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Renin-angiotensin system	KEGG	hsa04614
Systemic lupus erythematosus	KEGG	hsa05322
Lysosome	KEGG	ko04142
Lysosome	KEGG	hsa04142
Amoebiasis	KEGG	ko05146
Amoebiasis	KEGG	hsa05146
Metabolism of proteins	REACTOME	R-HSA-392499
Peptide hormone metabolism	REACTOME	R-HSA-2980736
Metabolism of Angiotensinogen to Angiotensins	REACTOME	R-HSA-2022377
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	REACTOME	R-HSA-381426
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Extracellular matrix organization	REACTOME	R-HSA-1474244
Degradation of the extracellular matrix	REACTOME	R-HSA-1474228
Activation of Matrix Metalloproteinases	REACTOME	R-HSA-1592389
Antimicrobial peptides	REACTOME	R-HSA-6803157
Neutrophil degranulation	REACTOME	R-HSA-6798695

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
19620298	2009	Human neutrophils kill Streptococcus pneumoniae via serine proteases.	68
2116408	1990	Identification of the primary antimicrobial domains in human neutrophil cathepsin G.	30
24929239	2014	Unopposed cathepsin G, neutrophil elastase, and proteinase 3 cause severe lung damage and emphysema.	29
22915586	2012	Clathrin pit-mediated endocytosis of neutrophil elastase and cathepsin G by cancer cells.	27
29976772	2018	Neutrophil Extracellular Traps Induce Endothelial Cell Activation and Tissue Factor Production Through Interleukin-1α and Cathepsin G.	27
15100291	2004	Cathepsin G, and not the asparagine-specific endoprotease, controls the processing of myelin basic protein in lysosomes from human B lymphocytes.	23
19528350	2009	Luminal cathepsin g and protease-activated receptor 4: a duet involved in alterations of the colonic epithelial barrier in ulcerative colitis.	22
14688365	2004	Proteolytic regulation of the urokinase receptor/CD87 on monocytic cells by neutrophil elastase and cathepsin G.	19
16444434	2006	Effect of various genetic polymorphisms on the incidence and outcome of severe sepsis.	16

Citation

Dessen P

CTSG (cathepsin G)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40205/ctsg-(cathepsin-g)