CUL1 (cullin 1)

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CUL1 (cullin 1)

2003-02-01 Affiliation

Identity

HGNC

LOCATION

7q36.1

LOCUSID

ALIAS

-

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8454
MIM: 603134
HGNC: 2551
Ensembl: ENSG00000055130

Variants:

dbSNP: 8454
ClinVar: 8454
TCGA: ENSG00000055130
COSMIC: CUL1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000055130	ENST00000325222	Q13616
ENSG00000055130	ENST00000325222	A0A090N7U0
ENSG00000055130	ENST00000409469	Q13616
ENSG00000055130	ENST00000409469	A0A090N7U0
ENSG00000055130	ENST00000602748	Q13616
ENSG00000055130	ENST00000602748	A0A090N7U0
ENSG00000055130	ENST00000617797	A0A0C4DGX4
ENSG00000055130	ENST00000655324	A0A590UK34
ENSG00000055130	ENST00000656001	A0A590UJ56
ENSG00000055130	ENST00000660013	A0A590UJA0
ENSG00000055130	ENST00000660240	A0A590UJC4
ENSG00000055130	ENST00000662132	A0A590UJ50
ENSG00000055130	ENST00000662670	A0A590UJ97
ENSG00000055130	ENST00000662716	Q13616
ENSG00000055130	ENST00000662716	A0A090N7U0
ENSG00000055130	ENST00000663044	Q13616
ENSG00000055130	ENST00000663044	A0A090N7U0
ENSG00000055130	ENST00000663835	A0A590UJR3
ENSG00000055130	ENST00000665936	Q13616
ENSG00000055130	ENST00000665936	A0A090N7U0
ENSG00000055130	ENST00000666124	A0A590UJ21
ENSG00000055130	ENST00000671397	A0A590UJM8
ENSG00000055130	ENST00000671421	A0A590UJ59

Expression (GTEx)

0

50

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cell cycle	KEGG	ko04110
Ubiquitin mediated proteolysis	KEGG	ko04120
Wnt signaling pathway	KEGG	ko04310
Hedgehog signaling pathway	KEGG	ko04340
TGF-beta signaling pathway	KEGG	ko04350
Circadian rhythm	KEGG	ko04710
Cell cycle	KEGG	hsa04110
Ubiquitin mediated proteolysis	KEGG	hsa04120
Wnt signaling pathway	KEGG	hsa04310
Hedgehog signaling pathway	KEGG	hsa04340
TGF-beta signaling pathway	KEGG	hsa04350
Circadian rhythm	KEGG	hsa04710
Oocyte meiosis	KEGG	ko04114
Oocyte meiosis	KEGG	hsa04114
Protein processing in endoplasmic reticulum	KEGG	ko04141
Protein processing in endoplasmic reticulum	KEGG	hsa04141
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
SCF-BTRC complex	KEGG	hsa_M00380
SCF-SKP2 complex	KEGG	hsa_M00381
SCF-FBS complex	KEGG	hsa_M00382
SCF-FBW7 complex	KEGG	hsa_M00387
SCF-FBS complex	KEGG	M00382
SCF-BTRC complex	KEGG	M00380
SCF-SKP2 complex	KEGG	M00381
SCF-FBW7 complex	KEGG	M00387
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
Signaling by NOTCH1 in Cancer	REACTOME	R-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in Cancer	REACTOME	R-HSA-2644602
Constitutive Signaling by NOTCH1 PEST Domain Mutants	REACTOME	R-HSA-2644606
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	REACTOME	R-HSA-2894858
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	REACTOME	R-HSA-2894862
FBXW7 Mutants and NOTCH1 in Cancer	REACTOME	R-HSA-2644605
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	REACTOME	R-HSA-2644607
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
TCR signaling	REACTOME	R-HSA-202403
Downstream TCR signaling	REACTOME	R-HSA-202424
Signaling by the B Cell Receptor (BCR)	REACTOME	R-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)	REACTOME	R-HSA-1168372
Activation of NF-kappaB in B cells	REACTOME	R-HSA-1169091
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradation	REACTOME	R-HSA-983168
Innate Immune System	REACTOME	R-HSA-168249
Toll-Like Receptors Cascades	REACTOME	R-HSA-168898
Toll Like Receptor 10 (TLR10) Cascade	REACTOME	R-HSA-168142
MyD88 cascade initiated on plasma membrane	REACTOME	R-HSA-975871
MAP kinase activation in TLR cascade	REACTOME	R-HSA-450294
Toll Like Receptor 3 (TLR3) Cascade	REACTOME	R-HSA-168164
MyD88-independent TLR3/TLR4 cascade	REACTOME	R-HSA-166166
TRIF-mediated TLR3/TLR4 signaling	REACTOME	R-HSA-937061
Toll Like Receptor 5 (TLR5) Cascade	REACTOME	R-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) Cascade	REACTOME	R-HSA-168181
MyD88 dependent cascade initiated on endosome	REACTOME	R-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	REACTOME	R-HSA-975138
Toll Like Receptor 9 (TLR9) Cascade	REACTOME	R-HSA-168138
Toll Like Receptor 4 (TLR4) Cascade	REACTOME	R-HSA-166016
Activated TLR4 signalling	REACTOME	R-HSA-166054
MyD88:Mal cascade initiated on plasma membrane	REACTOME	R-HSA-166058
Toll Like Receptor 2 (TLR2) Cascade	REACTOME	R-HSA-181438
Toll Like Receptor TLR1:TLR2 Cascade	REACTOME	R-HSA-168179
Toll Like Receptor TLR6:TLR2 Cascade	REACTOME	R-HSA-168188
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated NF-kB activation	REACTOME	R-HSA-2871837
C-type lectin receptors (CLRs)	REACTOME	R-HSA-5621481
CLEC7A (Dectin-1) signaling	REACTOME	R-HSA-5607764
Dectin-1 mediated noncanonical NF-kB signaling	REACTOME	R-HSA-5607761
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-1 signaling	REACTOME	R-HSA-446652
Prolactin receptor signaling	REACTOME	R-HSA-1170546
TNFR2 non-canonical NF-kB pathway	REACTOME	R-HSA-5668541
NIK-->noncanonical NF-kB signaling	REACTOME	R-HSA-5676590
Signal Transduction	REACTOME	R-HSA-162582
Signaling by NOTCH	REACTOME	R-HSA-157118
Signaling by NOTCH1	REACTOME	R-HSA-1980143
NOTCH1 Intracellular Domain Regulates Transcription	REACTOME	R-HSA-2122947
Signaling by Wnt	REACTOME	R-HSA-195721
Degradation of beta-catenin by the destruction complex	REACTOME	R-HSA-195253
Signaling by Hedgehog	REACTOME	R-HSA-5358351
Hedgehog 'off' state	REACTOME	R-HSA-5610787
GLI3 is processed to GLI3R by the proteasome	REACTOME	R-HSA-5610785
Degradation of GLI2 by the proteasome	REACTOME	R-HSA-5610783
Degradation of GLI1 by the proteasome	REACTOME	R-HSA-5610780
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
Mitotic G1-G1/S phases	REACTOME	R-HSA-453279
G1 Phase	REACTOME	R-HSA-69236
Cyclin D associated events in G1	REACTOME	R-HSA-69231
G1/S Transition	REACTOME	R-HSA-69206
Cyclin E associated events during G1/S transition	REACTOME	R-HSA-69202
SCF(Skp2)-mediated degradation of p27/p21	REACTOME	R-HSA-187577
S Phase	REACTOME	R-HSA-69242
Cyclin A:Cdk2-associated events at S phase entry	REACTOME	R-HSA-69656
Mitotic G2-G2/M phases	REACTOME	R-HSA-453274
G2/M Transition	REACTOME	R-HSA-69275
Regulation of PLK1 Activity at G2/M Transition	REACTOME	R-HSA-2565942
Regulation of mitotic cell cycle	REACTOME	R-HSA-453276
APC/C-mediated degradation of cell cycle proteins	REACTOME	R-HSA-174143
Regulation of APC/C activators between G1/S and early anaphase	REACTOME	R-HSA-176408
SCF-beta-TrCP mediated degradation of Emi1	REACTOME	R-HSA-174113
Circadian Clock	REACTOME	R-HSA-400253
MAP3K8 (TPL2)-dependent MAPK1/3 activation	REACTOME	R-HSA-5684264
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	REACTOME	R-HSA-8854050

Protein levels (Protein atlas)

Not detected

Low

Medium

High

cerebral cortex

cerebellum

hippocampus

caudate

thyroid gland

parathyroid gland

nasopharynx

bronchus

lung

oral mucosa

salivary gland

esophagus

stomach 1

stomach 2

duodenum

small intestine

colon

rectum

liver

gallbladder

pancreas

kidney

urinary bladder

testis

epididymis

seminal vesicle

prostate

vagina

ovary

fallopian tube

endometrium 1

endometrium 2

cervix, uterine

placenta

breast

heart muscle

smooth muscle

skeletal muscle

soft tissue 1

soft tissue 2

adipose tissue

skin 1

skin 2

appendix

spleen

lymph node

tonsil

References

Pubmed ID	Year	Title	Citations
38126621	2024	NNMT/1-MNA Promote Cell-Cycle Progression of Breast Cancer by Targeting UBC12/Cullin-1-Mediated Degradation of P27 Proteins.	3
38226814	2024	The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer.	2
38126621	2024	NNMT/1-MNA Promote Cell-Cycle Progression of Breast Cancer by Targeting UBC12/Cullin-1-Mediated Degradation of P27 Proteins.	3
38226814	2024	The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer.	2
37028429	2023	Systemwide disassembly and assembly of SCF ubiquitin ligase complexes.	7
37028429	2023	Systemwide disassembly and assembly of SCF ubiquitin ligase complexes.	7
33478195	2021	[Effects of Cullin1 on the Biological Characteristics of Lung Adenocarcinoma A549 and H1395 Cells].	0
33731859	2021	Reduced SKP1 and CUL1 expression underlies increases in Cyclin E1 and chromosome instability in cellular precursors of high-grade serous ovarian cancer.	15
34133001	2021	microRNA-377-3p inhibits osteosarcoma progression by targeting CUL1 and regulating Wnt/β-catenin signaling pathway.	4
34299191	2021	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	5
35008511	2021	A Comprehensive Assessment of Genetic and Epigenetic Alterations Identifies Frequent Variations Impacting Six Prototypic SCF Complex Members.	2
33478195	2021	[Effects of Cullin1 on the Biological Characteristics of Lung Adenocarcinoma A549 and H1395 Cells].	0
33731859	2021	Reduced SKP1 and CUL1 expression underlies increases in Cyclin E1 and chromosome instability in cellular precursors of high-grade serous ovarian cancer.	15
34133001	2021	microRNA-377-3p inhibits osteosarcoma progression by targeting CUL1 and regulating Wnt/β-catenin signaling pathway.	4
34299191	2021	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	5

Citation

Dessen P

CUL1 (cullin 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40211/case-report-explorer/js/lib/popper.js

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