CUL4A (cullin 4A)

2003-02-01  

Identity

HGNC
LOCATION
13q34
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 8451
MIM: 603137
HGNC: 2554
Ensembl: ENSG00000139842

Variants:

dbSNP: 8451
ClinVar: 8451
TCGA: ENSG00000139842
COSMIC: CUL4A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139842ENST00000326335A0A0A0MR50
ENSG00000139842ENST00000375440Q13619
ENSG00000139842ENST00000375441Q13619
ENSG00000139842ENST00000451881Q13619
ENSG00000139842ENST00000488558A0A087WWN2
ENSG00000139842ENST00000617546Q13619

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Nucleotide excision repairKEGGko03420
Ubiquitin mediated proteolysisKEGGko04120
Nucleotide excision repairKEGGhsa03420
Ubiquitin mediated proteolysisKEGGhsa04120
Cul4-DDB1-DDB2 complexKEGGhsa_M00385
Cul4-DDB1-CSA complexKEGGhsa_M00386
Cul4-DDB1-DDB2 complexKEGGM00385
Cul4-DDB1-CSA complexKEGGM00386
DNA RepairREACTOMER-HSA-73894
DNA Damage BypassREACTOMER-HSA-73893
Recognition of DNA damage by PCNA-containing replication complexREACTOMER-HSA-110314
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
DNA Damage Recognition in GG-NERREACTOMER-HSA-5696394
Formation of Incision Complex in GG-NERREACTOMER-HSA-5696395
Dual Incision in GG-NERREACTOMER-HSA-5696400
Transcription-Coupled Nucleotide Excision Repair (TC-NER)REACTOMER-HSA-6781827
Formation of TC-NER Pre-Incision ComplexREACTOMER-HSA-6781823
Dual incision in TC-NERREACTOMER-HSA-6782135
Gap-filling DNA repair synthesis and ligation in TC-NERREACTOMER-HSA-6782210

References

Pubmed IDYearTitleCitations
169493672006A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.300
169642402006Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.279
166781102006Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage.196
198186322009CRL4s: the CUL4-RING E3 ubiquitin ligases.161
164739352006The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites.142
147394642004Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase.139
209324712010CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation.127
164072522006PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination.124
187035162008CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation.124
168619062006L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage.97

Citation

Dessen P

CUL4A (cullin 4A)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40214/cul4a