CYP1B1 (cytochrome P450 family 1 subfamily B member 1)

2003-02-01  

Identity

HGNC
CYP1B1
LOCATION
2p22.2
LOCUSID
1545
ALIAS
ASGD6,CP1B,CYPIB1,GLC3A,P4501B1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1545
MIM: 601771
HGNC: 2597
Ensembl: ENSG00000138061

Variants:

dbSNP: 1545
ClinVar: 1545
TCGA: ENSG00000138061
COSMIC: CYP1B1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138061ENST00000490576A0A087WUQ7
ENSG00000138061ENST00000494864A0A087WW26
ENSG00000138061ENST00000610745Q16678
ENSG00000138061ENST00000614273Q16678

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Steroid hormone biosynthesisKEGGko00140
Tryptophan metabolismKEGGko00380
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Steroid hormone biosynthesisKEGGhsa00140
Tryptophan metabolismKEGGhsa00380
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
Ovarian steroidogenesisKEGGhsa04913
Ovarian steroidogenesisKEGGko04913
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)REACTOMER-HSA-2142816
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)REACTOMER-HSA-2142670
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cytochrome P450 - arranged by substrate typeREACTOMER-HSA-211897
Endogenous sterolsREACTOMER-HSA-211976

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD24958282
PA443560Breast NeoplasmsDiseaseClinicalAnnotationassociatedPD24599932, 24958282
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD
PA448404amodiaquineChemicalPathwayassociated
PA449165cyclophosphamideChemicalClinicalAnnotationassociatedPD24599932, 24958282
PA449383docetaxelChemicalPathwayassociated21151855
PA449412doxorubicinChemicalClinicalAnnotationassociatedPD
PA449476epirubicinChemicalClinicalAnnotationassociatedPD24599932, 24958282
PA450761paclitaxelChemicalClinicalAnnotation, PathwayassociatedPD21151855, 24599932
PA451257risperidoneChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
376610692024Enhancing the invasive traits of breast cancers by CYP1B1 via regulation of p53 to promote uPAR expression.1
377885972024Variable Phenotype of Congenital Corneal Opacities in Biallelic CYP1B1 Pathogenic Variants.0
384299212024CYP1B1 affects the integrity of the blood-brain barrier and oxidative stress in the striatum: An investigation of manganese-induced neurotoxicity.0
384798502024Circ_0020887 Silencing Combats Hypoxic-Induced Cardiomyocyte Injury in an MiR-370-3p/CYP1B1-Dependent Manner.0
387015132024Cytochrome P450 1B1 is critical in the development of TNF-α, IL-6, and LPS-induced cellular hypertrophy.0
376610692024Enhancing the invasive traits of breast cancers by CYP1B1 via regulation of p53 to promote uPAR expression.1
377885972024Variable Phenotype of Congenital Corneal Opacities in Biallelic CYP1B1 Pathogenic Variants.0
384299212024CYP1B1 affects the integrity of the blood-brain barrier and oxidative stress in the striatum: An investigation of manganese-induced neurotoxicity.0
384798502024Circ_0020887 Silencing Combats Hypoxic-Induced Cardiomyocyte Injury in an MiR-370-3p/CYP1B1-Dependent Manner.0
387015132024Cytochrome P450 1B1 is critical in the development of TNF-α, IL-6, and LPS-induced cellular hypertrophy.0
345262972023CYP1B1 and MYOC variants in neonatal-onset versus infantile-onset primary congenital glaucoma.3
364426822023Human CYP1B1 enzyme-mediated, AhR enhanced activation of aflatoxin B1 for its genotoxicity in human cells.1
366346302023CYP1B1 Genetic Variants (rs10916 and rs2855658) Are Associated with Increased Risk of Ischemic Stroke in Chinese Han Population.1
373711252023Human Adult Renal Progenitor Cells Prevent Cisplatin-Nephrotoxicity by Inducing CYP1B1 Overexpression and miR-27b-3p Down-Regulation through Extracellular Vesicles.0
374422342023Mitochondrial cytochrome P450 1B1 is involved in pregnenolone synthesis in human brain cells.1

Citation

Dessen P

CYP1B1 (cytochrome P450 family 1 subfamily B member 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40237/js/lib/css/lib/dataTables.bootstrap.min.css