DAD1 (defender against cell death 1)

2003-02-01  

Identity

HGNC
DAD1
LOCATION
14q11.2
LOCUSID
1603
ALIAS
OST2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1603
MIM: 600243
HGNC: 2664
Ensembl: ENSG00000129562

Variants:

dbSNP: 1603
ClinVar: 1603
TCGA: ENSG00000129562
COSMIC: DAD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129562ENST00000250498P61803
ENSG00000129562ENST00000535847F5H895
ENSG00000129562ENST00000538631A0A0B4J239
ENSG00000129562ENST00000543337F5GXX5

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
N-Glycan biosynthesisKEGGko00510
N-Glycan biosynthesisKEGGhsa00510
Metabolic pathwaysKEGGhsa01100
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
N-glycosylation by oligosaccharyltransferaseKEGGhsa_M00072
N-glycosylation by oligosaccharyltransferaseKEGGM00072
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
183832092008High-resolution analysis of genetic alterations in small bowel carcinoid tumors reveals areas of recurrent amplification and loss.23
204530002010A Large-scale genetic association study of esophageal adenocarcinoma risk.23
206770142010An approach based on a genome-wide association study reveals candidate loci for narcolepsy.16
216063202011Genetic associations with sporadic neuroendocrine tumor risk.7
215095942011Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma.6
300320712018Polymorphisms in the DAD1 and OXA1L genes are associated with asthma and atopy in a South American population.2
270860422016Comparative proteomic analysis of CD34(+) cells in bone marrow between severe aplastic anemia and normal control.0

Citation

Dessen P

DAD1 (defender against cell death 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40259/dad1