DMC1 (DNA meiotic recombinase 1)

2003-11-01  

Identity

HGNC
DMC1
LOCATION
22q13.1
LOCUSID
11144
ALIAS
DMC1H,LIM15,dJ199H16.1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11144
MIM: 602721
HGNC: 2927
Ensembl: ENSG00000100206

Variants:

dbSNP: 11144
ClinVar: 11144
TCGA: ENSG00000100206
COSMIC: DMC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100206ENST00000216024Q14565
ENSG00000100206ENST00000415483B0QYE1
ENSG00000100206ENST00000428462Q14565
ENSG00000100206ENST00000439567B0QYE0
ENSG00000100206ENST00000616615Q8IYL1

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
MeiosisREACTOMER-HSA-1500620
Meiotic recombinationREACTOMER-HSA-912446

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
151640662004Human meiotic recombinase Dmc1 promotes ATP-dependent homologous DNA strand exchange.70
176390812007Hop2/Mnd1 acts on two critical steps in Dmc1-promoted homologous pairing.57
185350082008A comparative analysis of Dmc1 and Rad51 nucleoprotein filaments.54
151258392004Structural basis for octameric ring formation and DNA interaction of the human homologous-pairing protein Dmc1.46
159172442005Activation of human meiosis-specific recombinase Dmc1 by Ca2+.42
175414042007Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1.42
203786152010Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.40
211511132011The resistance of DMC1 D-loops to dissociation may account for the DMC1 requirement in meiosis.25
181668242008Genetic investigation of four meiotic genes in women with premature ovarian failure.24
181668242008Genetic investigation of four meiotic genes in women with premature ovarian failure.24

Citation

Dessen P

DMC1 (DNA meiotic recombinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40337/dmc1-(dna-meiotic-recombinase-1)