DOCK3 (dedicator of cytokinesis 3)

2003-12-01  

Identity

HGNC
LOCATION
3p21.2
LOCUSID
ALIAS
MOCA,NEDIDHA,PBP
FUSION GENES

Other Information

Locus ID:

NCBI: 1795
MIM: 603123
HGNC: 2989
Ensembl: ENSG00000088538

Variants:

dbSNP: 1795
ClinVar: 1795
TCGA: ENSG00000088538
COSMIC: DOCK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000088538ENST00000266037Q8IZD9

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
203684332010Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex.34
190587892009A common variant in DRD3 receptor is associated with autism spectrum disorder.19
156474712005Modifier of cell adhesion regulates N-cadherin-mediated cell-cell adhesion and neurite outgrowth.16
200328192010Genetic variants in SLC9A9 are associated with measures of attention-deficit/hyperactivity disorder symptoms in families.16
193522182009Candidate gene analysis in an on-going genome-wide association study of attention-deficit hyperactivity disorder: suggestive association signals in ADRA1A.10
256870352015Inhibition of RAC1-GEF DOCK3 by miR-512-3p contributes to suppression of metastasis in non-small cell lung cancer.10
187160632008A novel functional screen in human cells identifies MOCA as a negative regulator of Wnt signaling.9
221150422012MOCA is an integrator of the neuronal death signals that are activated by familial Alzheimer's disease-related mutants of amyloid β precursor protein and presenilins.9
263196812016Dock3 Participate in Epileptogenesis Through rac1 Pathway in Animal Models.6

Citation

Dessen P

DOCK3 (dedicator of cytokinesis 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/40355/dock3-(dedicator-of-cytokinesis-3)