DRG1 (developmentally regulated GTP binding protein 1)

2003-02-01  

Identity

HGNC
DRG1
LOCATION
22q12.2
LOCUSID
4733
ALIAS
NEDD3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4733
MIM: 603952
HGNC: 3029
Ensembl: ENSG00000185721

Variants:

dbSNP: 4733
ClinVar: 4733
TCGA: ENSG00000185721
COSMIC: DRG1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185721ENST00000331457Q9Y295
ENSG00000185721ENST00000416465F8WEE0
ENSG00000185721ENST00000548143H0YI06
ENSG00000185721ENST00000629688F8WBU4

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
127025522003The Drg-1 gene suppresses tumor metastasis in prostate cancer.95
151848862004Role of the putative tumor metastasis suppressor gene Drg-1 in breast cancer progression.54
171788972006The tumor metastasis suppressor gene Drg-1 down-regulates the expression of activating transcription factor 3 in prostate cancer.41
190587892009A common variant in DRD3 receptor is associated with autism spectrum disorder.19
288556392017Developmentally Regulated GTP binding protein 1 (DRG1) controls microtubule dynamics.8
276264982016DRG1 is a potential oncogene in lung adenocarcinoma and promotes tumor progression via spindle checkpoint signaling regulation.7
237111552013Human Drg1 is a potassium-dependent GTPase enhanced by Lerepo4.6
259936552015Identification of DRG-1 As a Melanoma-Associated Antigen Recognized by CD4+ Th1 Cells.4

Citation

Dessen P

DRG1 (developmentally regulated GTP binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40362/drg1-(developmentally-regulated-gtp-binding-protein-1)