DUSP22 (dual specificity phosphatase 22)

2003-06-01  

Identity

HGNC
LOCATION
6p25.3
LOCUSID
ALIAS
JKAP,JSP-1,JSP1,LMW-DSP2,LMWDSP2,MKP-x,MKPX,VHX
FUSION GENES

Other Information

Locus ID:

NCBI: 56940
MIM: 616778
HGNC: 16077
Ensembl: ENSG00000112679

Variants:

dbSNP: 56940
ClinVar: 56940
TCGA: ENSG00000112679
COSMIC: DUSP22

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112679ENST00000344450Q9NRW4
ENSG00000112679ENST00000344450A0A384NLC8
ENSG00000112679ENST00000419235Q9NRW4
ENSG00000112679ENST00000603296S4R3A4
ENSG00000112679ENST00000603453S4R3M1
ENSG00000112679ENST00000603726S4R459
ENSG00000112679ENST00000603795S4R459
ENSG00000112679ENST00000603881S4R3K1
ENSG00000112679ENST00000604971S4R3M1
ENSG00000112679ENST00000605035S4R378
ENSG00000112679ENST00000605315S4R3M1
ENSG00000112679ENST00000605863S4R378

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
210305532011Discovery of recurrent t(6;7)(p25.3;q32.3) translocations in ALK-negative anaplastic large cell lymphomas by massively parallel genomic sequencing.67
244361312014Promoter hypermethylation of the phosphatase DUSP22 mediates PKA-dependent TAU phosphorylation and CREB activation in Alzheimer's disease.32
173846762007DUSP22/LMW-DSP2 regulates estrogen receptor-alpha-mediated signaling through dephosphorylation of Ser-118.17
263791512016Morphologic Features of ALK-negative Anaplastic Large Cell Lymphomas With DUSP22 Rearrangements.15
280179682017Mutations in NOTCH1 PEST domain orchestrate CCL19-driven homing of chronic lymphocytic leukemia cells by modulating the tumor suppressor gene DUSP22.14
227969202012Hypomethylation of dual specificity phosphatase 22 promoter correlates with duration of service in firefighters and is inducible by low-dose benzo[a]pyrene.13
275575002016Downregulation of the phosphatase JKAP/DUSP22 in T cells as a potential new biomarker of systemic lupus erythematosus nephritis.13
276266962016Molecular alterations and tumor suppressive function of the DUSP22 (Dual Specificity Phosphatase 22) gene in peripheral T-cell lymphoma subtypes.13
200188492010JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration.12
300934022018Molecular profiling reveals immunogenic cues in anaplastic large cell lymphomas with DUSP22 rearrangements.8

Citation

Dessen P

DUSP22 (dual specificity phosphatase 22)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40373/dusp22-(dual-specificity-phosphatase-22)