EFNA2 (ephrin A2)

2003-08-01  

Identity

HGNC
EFNA2
LOCATION
19p13.3
LOCUSID
1943
ALIAS
ELF-1,EPLG6,HEK7-L,LERK-6,LERK6
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1943
MIM: 602756
HGNC: 3222
Ensembl: ENSG00000099617

Variants:

dbSNP: 1943
ClinVar: 1943
TCGA: ENSG00000099617
COSMIC: EFNA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000099617ENST00000215368O43921

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHA-mediated growth cone collapseREACTOMER-HSA-3928663
EPH-ephrin mediated repulsion of cellsREACTOMER-HSA-3928665

References

Pubmed IDYearTitleCitations
337726062021Ephrin-A2 promotes prostate cancer metastasis by enhancing angiogenesis and promoting EMT.23
345238242021Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease.7
337726062021Ephrin-A2 promotes prostate cancer metastasis by enhancing angiogenesis and promoting EMT.23
345238242021Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease.7
265614742016Diagnostic and prognostic value of tissue and circulating levels of Ephrin-A2 in prostate cancer.2
265614742016Diagnostic and prognostic value of tissue and circulating levels of Ephrin-A2 in prostate cancer.2
245507312014CIB1 synergizes with EphrinA2 to regulate Kaposi's sarcoma-associated herpesvirus macropinocytic entry in human microvascular dermal endothelial cells.18
245507312014CIB1 synergizes with EphrinA2 to regulate Kaposi's sarcoma-associated herpesvirus macropinocytic entry in human microvascular dermal endothelial cells.18
240508522013The prognostic role of ephrin A2 and endothelial growth factor receptor pathway mediators in patients with advanced colorectal cancer treated with cetuximab.15
240508522013The prognostic role of ephrin A2 and endothelial growth factor receptor pathway mediators in patients with advanced colorectal cancer treated with cetuximab.15
222472582012EphA2 activation promotes the endothelial cell inflammatory response: a potential role in atherosclerosis.55
222472582012EphA2 activation promotes the endothelial cell inflammatory response: a potential role in atherosclerosis.55
195259192009Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex.69
195259192009Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex.69
178783882007Elf-1 binds to GGAA elements on the FcRgamma promoter and represses its expression.7

Citation

Dessen P

EFNA2 (ephrin A2)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40413/case-report-explorer/js/_common.js