ENPEP (glutamyl aminopeptidase)

2003-05-01  

Identity

HGNC
ENPEP
LOCATION
4q25
LOCUSID
2028
ALIAS
APA,CD249,gp160
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2028
MIM: 138297
HGNC: 3355
Ensembl: ENSG00000138792

Variants:

dbSNP: 2028
ClinVar: 2028
TCGA: ENSG00000138792
COSMIC: ENPEP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138792ENST00000265162Q07075
ENSG00000138792ENST00000509344H0YA67

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Renin-angiotensin systemKEGGko04614
Renin-angiotensin systemKEGGhsa04614
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Metabolism of Angiotensinogen to AngiotensinsREACTOMER-HSA-2022377

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
388862182024Uncovering the role of TET2-mediated ENPEP activation in trophoblast cell fate determination.0
388862182024Uncovering the role of TET2-mediated ENPEP activation in trophoblast cell fate determination.0
334218132021Aminopeptidase A (ENPEP) gene polymorphisms and preeclampsia: Descriptive analysis.0
338816112021Aminopeptidase A contributes to biochemical, anatomical and cognitive defects in Alzheimer's disease (AD) mouse model and is increased at early stage in sporadic AD brain.11
334218132021Aminopeptidase A (ENPEP) gene polymorphisms and preeclampsia: Descriptive analysis.0
338816112021Aminopeptidase A contributes to biochemical, anatomical and cognitive defects in Alzheimer's disease (AD) mouse model and is increased at early stage in sporadic AD brain.11
281778852017Aminopeptidase A initiates tumorigenesis and enhances tumor cell stemness via TWIST1 upregulation in colorectal cancer.12
281778852017Aminopeptidase A initiates tumorigenesis and enhances tumor cell stemness via TWIST1 upregulation in colorectal cancer.12
263111612015Local expression of AP/AngIV/IRAP and effect of AngIV on glucose-induced epithelial transport in human jejunal mucosa.0
263111612015Local expression of AP/AngIV/IRAP and effect of AngIV on glucose-induced epithelial transport in human jejunal mucosa.0
248852402014Altered glutamyl-aminopeptidase activity and expression in renal neoplasms.4
248852402014Altered glutamyl-aminopeptidase activity and expression in renal neoplasms.4
238880462013Structural insights into central hypertension regulation by human aminopeptidase A.21
240984522013miR-125b acts as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-α, CCNJ, and MEGF9.75
238880462013Structural insights into central hypertension regulation by human aminopeptidase A.21

Citation

Dessen P

ENPEP (glutamyl aminopeptidase)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40454/tumors-explorer/tumors-explorer/css/lib/bootstrap.min.css