EPHA8 (EPH receptor A8)

2003-02-01  

Identity

HGNC
LOCATION
1p36.12
LOCUSID
ALIAS
EEK,EK3,HEK3

Other Information

Locus ID:

NCBI: 2046
MIM: 176945
HGNC: 3391
Ensembl: ENSG00000070886

Variants:

dbSNP: 2046
ClinVar: 2046
TCGA: ENSG00000070886
COSMIC: EPHA8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000070886ENST00000166244P29322
ENSG00000070886ENST00000374644P29322

Expression (GTEx)

0
1
2
3
4
5

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHA-mediated growth cone collapseREACTOMER-HSA-3928663
EPH-ephrin mediated repulsion of cellsREACTOMER-HSA-3928665

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
256830042015miR-10a controls glioma migration and invasion through regulating epithelial-mesenchymal transition via EphA8.21
157821142005The EphA8 receptor induces sustained MAP kinase activation to promote neurite outgrowth in neuronal cells.19
126814842003The p110 gamma PI-3 kinase is required for EphA8-stimulated cell migration.5
222919912012RINL, guanine nucleotide exchange factor Rab5-subfamily, is involved in the EphA8-degradation pathway with odin.5
275824842017Targeted Sequencing Reveals Low-Frequency Variants in EPHA Genes as Markers of Paclitaxel-Induced Peripheral Neuropathy.5
269890752016EphA8 is a prognostic marker for epithelial ovarian cancer.3
200294092010Association of polymorphisms in the SLIT2 axonal guidance gene with anger in suicide attempters.2
303003342018EphA8 is a Prognostic Factor for Oral Tongue Squamous Cell Carcinoma.1
310260692019EphA8 acts as an oncogene and contributes to poor prognosis in gastric cancer via regulation of ADAM10.0

Citation

Dessen P

EPHA8 (EPH receptor A8)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40467/epha8